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- Aspetos socioeconómicos da Diabetes Mellitus em Pemba, Moçambique: estudo de casoPublication . Michal, Soares; Carapeto, CristinaIntrodução: Apesar da diabetes mellitus ser uma condição cujo tratamento, causas e consequências são bem conhecidas, a sua prevalência continua a aumentar sendo a sua incidência comparável à das epidemias. Objetivos: O principal objetivo do presente estudo foi averiguar se os portadores da DMII que recorrem ao Hospital de Pemba, Moçambique, têm condições socioeconómicas para seguir a dieta que lhes é recomendada para o controlo da sua condição. Resultados: Foram incluídos neste estudo de caso 28 pacientes sendo que se optou por um questionário de frequência alimentar e questões relacionadas com o dia-a-dia dos pacientes cujos resultados foram relacionados com a variável dependente classe social. Verificou-se haver uma dificuldade generalizada no acesso aos alimentos independentemente da classe social dos inquiridos. Também se verificou existir um elevado nível de consciência por parte dos inquiridos no que respeita à DMII e seu tratamento. Conclusão: As condições socioeconómicas da população em estudo determina o seu nível de adesão à DMII muito em especial no que concerne à adoção de um padrão alimentar favorável ao controlo da condição.
- Biochemical endpoints on juvenile Solea senegalensis exposedPublication . Costa, Pedro M.; Caeiro, Sandra; Diniz, Mário S.; Lobo, Jorge; Martins, Marta; Ferreira, Ana M.; Caetano, Miguel; Vale, Carlos; DelValls, T. Ángel; Costa, Maria HelenaJuvenile Solea senegalensis were exposed to fresh sediments from three stations of the Sado estuary (Portugal) in 28-day laboratory assays. Sediments revealed distinct levels of total organic matter, fine fraction, redox potential, trace elements (arsenic, cadmium, chromium, copper, nickel, lead and zinc) and organic contaminants (polycyclic aromatic hydrocarbons, polychlorinated biphenyls and a pesticide: dichloro diphenyl trichloroethane). Organisms were surveyed for contaminant bioaccumulation and induction of two hepatic biochemical biomarkers: metallothionein (MT) and cytochrome P450 (CYP1A), as potential indicators of exposure to metallic and organic contaminants, respectively. Using an integrative approach it was established that, although bioaccumulation is in general accordance with sediment contamination, lethality and biomarker responses are not linearly dependent of the cumulative concentrations of sediment contaminants but rather of their bioavailability and synergistic effects in organisms. It is concluded that metals and organic contaminants modulate both MT and CYP1A induction and it is suggested that reactive oxygen species may be the link between responses and effects of toxicity.
- Economic impact of healthcare cyber risksPublication . Brilhante, Maria de Fátima; Mendonça, Sandra; Pestana, Pedro Duarte; Rocha, Maria Luísa; Santos, RuiPurpose: The healthcare sector is a primary target for cybercriminals, with health data breaches ranking among the most critical threats. Despite stringent penalties imposed by the U.S. Department of Health and Human Services Office for Civil Rights (OCR), vulnerabilities still persist due to slow detection and ineffective data protection measures. On the other hand, as organizations are often reluctant to disclose security breaches for fear of reputational and market share losses, penalties can serve as a useful proxy for quantifying losses and insurance claims. Methods: This study analyzes fines and settlements (2008–2024) using the traditional lognormal, general extreme value (GEV) and other heavy-tailed statistical models, including the geo-max-stable loglogistic law, and also the mixture models hyperexponential and hyperloglogistic. Results: Mixture models, either the hyperexponential or the hyperloglogistic, deliver the best fit for OCR penalties, and for yearly maxima, the best fit is achieved with the GEV distribution. Regarding Attorneys General fines, the hyperexponential model is optimal, with the GEV model excelling again for their yearly maxima. Hence, mixture models effectively capture the dual nature of penalty data, comprising clusters of moderate and extreme values. However, yearly maxima align better with the GEV model. Conclusions: The findings suggest that while Panjer’s theory for aggregate claims suffices for moderate claims, it must be supplemented with strategies to address extreme cybercrime scenarios, ensuring insurers and reinsurers can manage severe losses effectively.
- Estruturas Metalo-Orgânicas (MOFs) e Polímeros de Coordenação (PCs) no Instituto Superior Técnico: síntese e aplicações atuaisPublication . Kirillov, Alexander M.; Fernandes, Tiago; Pinto, Rosana V.; Bordonhos, Marta; Mohtar, Abeer; Pinto, Moisés L.Este artigo destaca mais de uma década de investigação no Instituto Superior Técnico (IST, ULisboa), conduzida pelos grupos de Moisés L. Pinto (CERENA) e Alexander Kirillov (CQE), com foco no design personalizado de estruturas metalo-orgânicas (MOFs) e polímeros de coordenação (PCs). Os materiais desenvolvidos revelam um enorme potencial na separação de gases, purificação do ar e em aplicações biomédicas, incluindo a libertação controlada de gases terapêuticos e propriedades antimicrobianas. Estes exemplos ilustram como o controlo preciso da estrutura destes materiais permite criar soluções para desafios atuais, abrindo caminho a tecnologias que podem transformar a indústria, o ambiente e a saúde.
- A gestão dos resíduos urbanos no município de Teresópolis: uma avaliação socioambientalPublication . Gomes, Natalia; Carapeto, CristinaEm 1987, o Relatório Brundtland apontou a necessidade de promover o crescimento sustentável, uma vez que a escalada populacional e industrial estavam causando enormes desafios ao meio ambiente. A geração de resíduos excedentes no Brasil é reflexo de uma política de alto consumo que esgota os recursos não renováveis, causando desequilíbrios ambientais e problemas associados ao descarte inadequado de resíduos urbanos. Por isso, a busca por soluções adequadas para o tratamento e disposição final dos resíduos é alvo das políticas setoriais no Brasil e no mundo. Em Teresópolis, o Aterro Sanitário da Prata é o local de disposição final dos resíduos sólidos urbanos. Devido às condições precárias e ao mau funcionamento, o Aterro acaba sendo um lixão e, consequentemente, não corresponde à Política Nacional de Resíduos Sólidos, gerando impactos sociais e ambientais. A identificação dos custos socioambientais da gestão do aterro sanitário de Teresópolis e a busca de possíveis soluções para solucionar ou melhorar a situação sanitária atual foram identificadas com uma investigação exploratória e dados de levantamentos juntamente com pesquisa documental e visitas ao local.
- Impact of the COVID-19 pandemic on the financial situation of rural and urban households in PolandPublication . Głowicka-Wołoszyn, Romana; Wołoszyn, Andrzej; Stanisławska, Joanna; Oliveira, Amilcar; Oliveira, Teresa A.The COVID-19 pandemic not only caused a global health crisis but also had a huge impact on household finances. This research aimed to examine the financial situation of rural and urban households in Poland between 2018 and 2022 from a multidimensional perspective. In a unidimensional approach, the financial situation of households was analyzed separately for their income, expenditures, savings rate, and shares of fixed expenses. In a multidimensional approach, the analysis used a synthetic index constructed for all these variables combined, employing the TOPSIS method and drawing on microdata from the Polish Central Statistical Office that totaled approximately 150,000 households. It was found that despite the pandemic outbreak, which led to major changes in the labor market, government-introduced organizational and legal measures protected the income of Polish households from decline. Indeed, income was increasing up until 2021, with a modest fall in 2022, which was less severe in rural households (by about 2%) than in urban ones (by 6%). A more immediate response to the outbreak was observed in consumer spending, which fell sharply, while the food share in consumption increased at similar levels in rural and urban areas. Regression analysis showed that compared to 2019, the pandemic worsened the financial situation of Polish households, but only in 2020 and 2022 were these changes statistically significant. In 2021, the financial situation improved slightly, but the change was not statistically significant. Before the pandemic, the synthetic assessment of the financial situation in rural areas was lower than in urban ones, and the pandemic period did not reduce these differences, showing no convergence between poorer rural areas and richer urban ones. Diagnosing and monitoring the household financial situation are crucial steps for achieving the social dimension goals of sustainable development. Research on the pandemic’s effects on household finances provides valuable information that can help develop effective strategies to counter future crises while supporting the social dimension of the sustainable development strategy.
- Innovating for tomorrow: industry 4.0’s role in sustainable healthcarePublication . Ferreira, Ana Rita O.; Fernandes, TiagoPurpose: It is essential for professionals to stay informed about the revolution we are witnessing and understand the related technical concepts in today’s rapidly evolving society. In addition to exploring how Industry 4.0 technologies—such as artificial intelligence (AI), the Internet of Things (IoT), big data, and blockchain—are transforming the healthcare sector, this literature review aims to address a crucial question: How can new technologies improve operational and environmental sustainability in healthcare while maintaining accessibility, safety, and equity? Methods: A comprehensive literature study was conducted to analyze current research and discussions around the integration of Industry 4.0 technology in healthcare. This paper covers the various aspects of automation, data processing, system interconnection, ethical, financial, and infrastructure issues. Among the main topics discussed is data integration, which helps to enhance resource management, predictive analytics, and decision-making. Results: Through international case studies (Mayo Clinic, Cleveland Clinic, Manifal Hospital, University College London Hospitals, Charité Hospital, Mount Sinai Hospital, Centro Hospitalar e Universitário de Coimbra) this review shows how these technologies improve patient outcomes, healthcare efficiency, and the environment. Significant problems should be warned about, including ethical issues about patient data security and privacy, unequal access to technological developments, the necessity of guaranteeing health information system interoperability, and economic viability concerns, particularly in countries or regions with limited resources. Conclusions: Healthcare 4.0 has enormous potential for global justice and sustainability, but its ethical integrity, data security, and broad accessibility must be monitored. Although the healthcare sector will benefit much from the 4th industrial revolution, this analysis cautions about the related social and economic issues and inequalities. Encouraging ethical innovation will rely much on public policies to support this technological transition being implemented in a sustainable manner in the healthcare sector.
- Planning cities for pandemics: review of urban and transport planning lessons from COVID-19Publication . Monteiro, João Pedro Medina; Sousa, Nuno; Pais, Filipe; Rodrigues, João Coutinho; Jesus, Eduardo NatividadeFor the past few years, the world has been facing one of the worst pandemics of modern times. The COVID-19 outbreak joined a long list of infectious diseases that turned pandemic, and it will most likely leave scars and change how humans live, plan and manage urban space and its infrastructures. Many fields of science were called into action to mitigate the impacts of this pandemic, including spatial and transport planning. Given the large number of papers recently published in these research areas, it is time to carry out an overview of the knowledge produced, and synthesising, systematising and critically analysing it. This paper aims to review how the urban layout, accessibility and mobility influence the spread of a virus in an urban environment and what solutions exist or have been proposed to create a more effective and less intrusive response to pandemics. This review is split into two avenues of research: spatial planning and transport planning, including the direct and indirect impact on the environment and sustainability.
- Pylung: a supporting tool for comparative study of ViT and CNN-based models used for lung nodules classificationPublication . Marques, Felipe; Pestana, Pedro Duarte; Filipe, VitorLung cancer is a significant global health concern, and accu- rate classification of lung nodules plays a crucial role in its early detec- tion and treatment. This paper evaluates and compares the performance of Vision Transformer (ViT) and Convolutional Neural Network (CNN) models for lung nodule classification using the Pylung tool proposed in this work. The study aims to address the lack of research on ViT in lung nodule classification and proposes ViT as an alternative to CNN. The Lung Image Database Consortium and Image Database Resource Ini- tiative (LIDC-IDRI) dataset is utilized for training and evaluation. The Pylung tool is employed for dataset preprocessing and comparison of models. Three models, ViT, VGG16, and ResNet50, are analyzed, and their hyperparameters are optimized using Optuna. The results show that ViT achieves the highest accuracy (99.06%) in nodule classifica- tion compared to VGG16 (98.71%) and ResNet50 (98.46%). The study contributes by introducing ViT as a model for lung nodule classification, presenting the Pylung tool for model comparison, and suggesting further investigations to improve the accuracy.
- Stochastic response surface methodology: a study in the human health areaPublication . Leal, Maria da Conceição Dias; Oliveira, Amilcar; Oliveira, Teresa A.In this paper we review Stochastic Response Surface Methodology as a tool for modeling uncertainty in the context of Risk Analysis. An application in the survival analysis in the breast cancer context is implemented with R software.