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Modeling anesthetic drugs' pharmacodynamic interaction on the bispectral index of the EEG: the influence of heart rate
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Advisor(s)
Abstract(s)
The effect of drugs’ interaction on the brain signal
Bispectral Index (BIS) is of great importance for an anesthesia
control drug infusion system. In this study, the objective was
to inspect the influence of patient’s heart rate on the effect
of the drugs on BIS. With this goal, the patient’s heart rate
was incorporated in an drug interaction model. The model was
fitted per patient during anesthesia induction, and tested for
prediction under surgery. The results showed that the model
with time changing parameters incorporating patient’s heart
rate has a better performance than a non adjusted model.
Three clusters of models were also identified using the fuzzy cmeans algorithm. These clusters will help to distinguish between
different patients’ dynamics.
Description
Keywords
Citation
C. S. Nunes, T. Mendonca, S. Bras, D. A. Ferreira and P. Amorim, "Modeling Anesthetic Drugs' Pharmacodynamic Interaction on the Bispectral Index of the EEG: the Influence of Heart Rate," 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Lyon, France, 2007, pp. 6479-6482
