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The effects of different concentrations of the α2-Adrenoceptor Agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice

2015Journal article Open access
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dc.contributor.authorRibeiro, Patrícia O.
dc.contributor.authorAntunes, Luis M.
dc.contributor.authorNunes, Catarina S.
dc.contributor.authorSilva, Henrique B.
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorTomé, Ângelo R.
dc.date.accessioned2021-05-13T12:09:41Z
dc.date.available2021-05-13T12:09:41Z
dc.date.issued2015
dc.description.abstractα2-Adrenoceptor agonists are used frequently in human and veterinary anesthesia as sedative/analgesic drugs. However, they can impair cognition. Little is known about the concentration-dependent effects of α2-adrenoceptor agonists on synaptic plasticity, the neurophysiological basis of learning and memory. Therefore, we investigated the effects of different concentrations of medetomidine, an α2-adrenoceptor agonist, on basal excitatory synaptic transmission and on 2 forms of synaptic plasticity: paired-pulse facilitation (PPF) and long-term potentiation (LTP).pt_PT
dc.description.sponsorshipThis work was supported by FCT (Lisbon, Portugal) and cofunded by COMPETE: 01-0124-FEDER-009497 (Lisbon, Portugal), through the project grants PTDC/CVT/099022/2008 and PTDC/SAU-NSC/122254/2010 and through a personal PhD grant (SFRH /BD/48883/2008) to Patrícia do Céu Oliveira Ribeiro and by QREN (09-68-ESR-FP-010).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, Patrícia O. DVM, PhD*; Antunes, Luis M. DVM, PhD†‡; Nunes, Catarina S. MSc, PhD§‖; Silva, Henrique B. PhD*; Cunha, Rodrigo A. PhD*¶; Tomé, Ângelo R. PhD*# The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice, Anesthesia & Analgesia: May 2015 - Volume 120 - Issue 5 - p 1130-1137 doi: 10.1213/ANE.0000000000000636pt_PT
dc.identifier.doi10.1213/ANE.0000000000000636pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.2/10731
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Healthpt_PT
dc.relationEffects of Ketamine anaesthesia in animal models used on research
dc.relationOS EFEITOS DA COMBINAÇÃO ANESTÉSICA CETAMINA/MEDETOMIDINA A NÍVEL CEREBRAL EM MURGANHOS ADULTOS
dc.relation.publisherversionhttps://journals.lww.com/anesthesia-analgesia/Fulltext/2015/05000/The_Effects_of_Different_Concentrations_of_the.31.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdrenergic alpha-2 receptor agonistspt_PT
dc.subjectAge factorspt_PT
dc.subjectAnimalspt_PT
dc.subjectCA1 Region, Hippocampalpt_PT
dc.subjectDose-response relationship, Drugpt_PT
dc.subjectEvoked potentialspt_PT
dc.subjectExcitatory postsynaptic potentialspt_PT
dc.subjectFemalept_PT
dc.subjectIn vitro techniquespt_PT
dc.subjectLong-term synaptic depressionpt_PT
dc.subjectMedetomidinept_PT
dc.subjectMemorypt_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred BALB Cpt_PT
dc.subjectNeuronal plasticitypt_PT
dc.subjectPyramidal cellspt_PT
dc.subjectSynaptic transmissionpt_PT
dc.subjectTime factorspt_PT
dc.titleThe effects of different concentrations of the α2-Adrenoceptor Agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEffects of Ketamine anaesthesia in animal models used on research
oaire.awardTitleOS EFEITOS DA COMBINAÇÃO ANESTÉSICA CETAMINA/MEDETOMIDINA A NÍVEL CEREBRAL EM MURGANHOS ADULTOS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FCVT%2F099022%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-NSC%2F122254%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F48883%2F2008/PT
oaire.citation.endPage1137pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1130pt_PT
oaire.citation.titleAnesthesia & Analgesiapt_PT
oaire.citation.volume120pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamFARH
person.familyNameNunes
person.givenNameCatarina S.
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0002-8357-0994
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isProjectOfPublication24d3e54e-c2a9-4b53-9aa6-324cd9301812
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