The effects of different concentrations of the α2-Adrenoceptor Agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice

Ribeiro, Patrícia O.; Antunes, Luis M.; Nunes, Catarina S.; Silva, Henrique B.; Cunha, Rodrigo A.; Tomé, Ângelo R.

http://hdl.handle.net/10400.2/10731

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Abstract(s)

α2-Adrenoceptor agonists are used frequently in human and veterinary anesthesia as sedative/analgesic drugs. However, they can impair cognition. Little is known about the concentration-dependent effects of α2-adrenoceptor agonists on synaptic plasticity, the neurophysiological basis of learning and memory. Therefore, we investigated the effects of different concentrations of medetomidine, an α2-adrenoceptor agonist, on basal excitatory synaptic transmission and on 2 forms of synaptic plasticity: paired-pulse facilitation (PPF) and long-term potentiation (LTP).

Keywords

Adrenergic alpha-2 receptor agonists Age factors Animals CA1 Region, Hippocampal Dose-response relationship, Drug Evoked potentials Excitatory postsynaptic potentials Female In vitro techniques Long-term synaptic depression Medetomidine Memory Mice Mice, Inbred BALB C Neuronal plasticity Pyramidal cells Synaptic transmission Time factors

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http://hdl.handle.net/10400.2/10731

Citation

Ribeiro, Patrícia O. DVM, PhD*; Antunes, Luis M. DVM, PhD†‡; Nunes, Catarina S. MSc, PhD§‖; Silva, Henrique B. PhD*; Cunha, Rodrigo A. PhD*¶; Tomé, Ângelo R. PhD*# The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice, Anesthesia & Analgesia: May 2015 - Volume 120 - Issue 5 - p 1130-1137 doi: 10.1213/ANE.0000000000000636