Publication
Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients
| dc.contributor.author | Nunes, Catarina S. | |
| dc.contributor.author | Ferreira, David A. | |
| dc.contributor.author | Antunes, Luís | |
| dc.contributor.author | Lobo, Francisco | |
| dc.contributor.author | Santos, Isabel A. | |
| dc.contributor.author | Amorim, Pedro | |
| dc.date.accessioned | 2023-05-29T15:10:47Z | |
| dc.date.available | 2023-05-29T15:10:47Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Study Objective: To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design: Prospective study. Setting: Operating room. Patients: 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score N 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions: A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL 1 . Main Results: Propofol concentration at LOC was 4.9 ± 1 μg mL 1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μg mL 1 and 3.41 ± 1.5 ng mL 1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions: The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Nunes, C.S., D. Ferreira, L. Antunes, F. Lobo, I. Santos, and P. Amorim (2009) "Individual Effect-Site Concentrations of Propofol at Return of Consciousness are Related to the Concentrations at Loss of Consciousness and Age in Neurosurgical Patients," Journal of Clinical Anesthesia, 21(1): 3-8 | pt_PT |
| dc.identifier.doi | 10.1016/j.jclinane.2008.06.011 | pt_PT |
| dc.identifier.issn | 1873-4529 | |
| dc.identifier.uri | http://hdl.handle.net/10400.2/13884 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | Consciousness, loss of | pt_PT |
| dc.subject | Consciousness, return to | pt_PT |
| dc.subject | Drug dosages: effect-site concentrations | pt_PT |
| dc.subject | Propofol, hypnotic dose | pt_PT |
| dc.title | Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 8 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 3 | pt_PT |
| oaire.citation.title | Journal of Clinical Anesthesia | pt_PT |
| oaire.citation.volume | 21 | pt_PT |
| person.familyName | Nunes | |
| person.familyName | Amorim | |
| person.givenName | Catarina S. | |
| person.givenName | Pedro | |
| person.identifier.ciencia-id | 691F-CDC2-E26A | |
| person.identifier.orcid | 0000-0002-8357-0994 | |
| person.identifier.orcid | 0000-0001-7466-4174 | |
| person.identifier.scopus-author-id | 55429654100 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | cc3069ec-f930-455f-9226-b77e5d2dc14b | |
| relation.isAuthorOfPublication | 1ef321dd-4f09-493c-b801-e9a99b28947d | |
| relation.isAuthorOfPublication.latestForDiscovery | cc3069ec-f930-455f-9226-b77e5d2dc14b |