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Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients
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Advisor(s)
Abstract(s)
Study Objective: To investigate whether a patient's propofol effect-site concentration at return to
consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness
(LOC) and to patients' individual demographic parameters.
Design: Prospective study.
Setting: Operating room.
Patients: 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score N 15, and
scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of
propofol and remifentanil.
Interventions: A constant propofol infusion was administered until LOC. At LOC, remifentanil started
with a plasma concentration target of 2.5 ng mL 1
.
Main Results: Propofol concentration at LOC was 4.9 ± 1 μg mL 1
. At ROC, propofol and remifentanil
concentrations were 1.16 ± 0.3 μg mL 1 and 3.41 ± 1.5 ng mL 1
. Significant correlation was observed
between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient
age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age.
Conclusions: The correlation between propofol concentrations at ROC and LOC was improved by
inclusion of patient age data.
Description
Keywords
Consciousness, loss of Consciousness, return to Drug dosages: effect-site concentrations Propofol, hypnotic dose
Citation
Nunes, C.S., D. Ferreira, L. Antunes, F. Lobo, I. Santos, and P. Amorim (2009) "Individual Effect-Site Concentrations of Propofol at Return of Consciousness are Related to the Concentrations at Loss of Consciousness and Age in Neurosurgical Patients," Journal of Clinical Anesthesia, 21(1): 3-8
Publisher
Elsevier