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Publication
Multivariable fuzzy control for the simultaneous administration of the anaesthetic and the analgesic drugs
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Advisor(s)
Abstract(s)
A multivariable fuzzy controller developed for the simultaneous administration of the
anaesthetic drug (propofol) and the analgesic drug (remifentanil), is presented. The controller was
designed in order to achieve a steady state level of depth of anaesthesia (DOA) and to reduce the
amount of drug infused. The multivariable fuzzy controller is based on linguistic rules that interact with
three decision tables, one of which represents a fuzzy PI controller. Optimisation using genetic
algorithms was used to determine the scaling factors of the fuzzy PI controller. According to the
different possibilities for the DOA level and for the surgical stimuli, the multivariable controller
defines the required change in the infusion rates of the two drugs. A patient model of the interaction
between propofol and remifentanil was used to test the multivariable controller. The controller was able
to adjust the remifentanil infusion rate according to the stimulus intensity, and takes advantage of the
synergistic interaction to the change adequately the propofol infusion rate. Propofol is titrated to lower
infusion rates, decreasing the amount of drug infused, and speeding up recovery. In addition, the
controller ensures adequate analgesia by titrating the remifentanil according to stimulus. The
multivariable fuzzy controller was tested under different simulations, and responded efficiently to
different induction profiles, set point changes and disturbances.
Description
Keywords
Multivariable control Fuzzy logic Depth of anaesthesia Analgesia Synergistic interactions
Citation
C. S. Nunes, M. Mahfouf, D. A. Linkens and J. Peacock, "Multivariable fuzzy control for the simultaneous administration of the anaesthetic and the analgesic drugs," 2003 European Control Conference (ECC), Cambridge, UK, 2003, pp. 1046-1051
Publisher
IEEE