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- Rocuronium continuous infusion for profound neuromuscular blockade: a systematic review and meta-analysisPublication . Couto, Mafalda; Nunes, Catarina S.; Vide, Sérgio; Amorim, Pedro; Mendes, JoaquimRocuronium is a muscle relaxant with increased use, because of the binding relation with the reversal agent sugammadex. Its continuous infusion benefits the maintenance of deeper levels of neuromuscular blockade (NMB) ensuring an improved and stable solution for daily surgical anesthesia. This is systematic review on current approaches on rocuronium infusion and monitoring parameters when using rocuronium continuous infusion for profound muscle relaxation (0-2 posttetanic count).
- Patterns of hysteresis between induction and emergence of neuroanesthesia are present in spinal and intracranial surgeriesPublication . Ferreira, Ana Isabel Leitão; Correia, Rui; Vide, Sérgio; Ferreira, Ana Dias; Kelz, Max B.; Mendes, Joaquim; Nunes, Catarina S.; Amorim, PedroRecovery of consciousness is usually seen as a passive process, with emergence from anesthesia depicted as the inverse process of induction resulting from the elimination of anesthetic drugs from their central nervous system sites of action. However, that need not be the case. Recently it has been argued that we might encounter hysteresis to changes in the state of consciousness, known as neural inertia. This phenomenon has been debated in neuroanesthesia, as manipulation of the brain might further influence recovery of consciousness. The present study is aimed at assessing hysteresis between induction and emergence under propofol-opioid neuroanesthesia in humans using estimated propofol concentrations in both spinal and intracranial surgeries.