Matemática e Estatística | Capítulos/artigos em livros internacionais / Book chapters/papers in international books
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Browsing Matemática e Estatística | Capítulos/artigos em livros internacionais / Book chapters/papers in international books by Subject "Biomedical systems"
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- A fuzzy patient model in anaesthesiaPublication . Nunes, Catarina S.; Mahfouf, M.; Linkens, D. A.Balanced anaesthesia introduces the problem of drug interactions. In this article, the effect concentrations of anaesthetic and analgesic are used to model the pharmacodynamic interactions of the two drugs on the cardiovascular parameters, and on the auditory evoked potentials. An adaptive network-based fuzzy inference system is used to model the different signals. A stimulus model is used to establish the effects of surgical stimulus on the cardiovascular parameters. This model, is constructed into a Mamdani type of fuzzy model, using the anaesthetist knowledge described by fuzzy IF-THEN rules. Clinical data is used to construct the patient model.
- Garch models for drug effects on patient heart rate, during general anaesthesiaPublication . Brás, Susana; Nunes, Catarina S.; Amorim, PedroA model that can describe the effect of anaesthetic drugs on patient’s heart rate (HR) is of great importance when considering haemodynamic stability under surgery. A Generalized Autoregressive Conditional Heteroscedasticity (GARCH) model was used to model HR considering the effect concentrations of the anaesthetic propofol and the analgesic remifentanil, using the clinical data of 16 patients. The model was able to capture the HR trend in all 16 patients with very small errors throughout the surgical time. A correlation was found between the GARCH parameters and patient baseline characteristics, leading to the possibility a patient adjusted adaptive model.
- Modelling drugs' pharmacodynamic interaction during general anaesthesia: the choice of pharmacokinetic modelPublication . Nunes, Catarina S.; Mendonça, Teresa F.; Antunes, Luís; Ferreira, David A.; Lobo, Francisco; Amorim, PedroThe effect of drugs’ interaction on the brain signal Bispectral Index (BIS) is of great importance for an anaesthesia control drug infusion system. In this study, two renowned pharmacokinetic (PK) models for propofol are compared, in order to evaluate its influence on the performance/predictably of a drug interaction model for BIS, considering data of 45 patients. The model was fitted per patient during anaesthesia induction, and tested for prediction under surgery. The results showed that the choice of PK model had influence on the overall performance. In the prediction phase, only one PK model presented good results with small errors.