Browsing by Author "Silva, A. P."
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- Acid phosphatase, some genetic polymorphism and obesity risk factors in adult womenPublication . Carolino, E.; Oliveira, T.; Silva, A. P.; Carvalho, R; Bicho, M.Recent works point out to a relation between some genetic factors and the predisposition for obesity. We believe, therefore, to be relevant to conduct this kind of study in the Portuguese population. In the present work the following genetic factors are considered: Haptoglobin phenotype, the Acid Phosphatasehenotype and two blood group systems, the MN System and the Lewis System. In addition, it was also considered one demographic factor, age, and one enzymatic activity, the Acid Phosphatase Activity. Haptoglobin (Hp) is a hemoglobin-binding protein of the immune system expressed by a genetic polymorphism with three major phenotypes. This protein is associated in some works with susceptibility for common pathological situations, such as some disorders related with obesity. The Acid phosphatase, more precisely the Acid phosphatase locus 1 (ACP1), is a highly polymorphic enzyme that has an important role in flavoenzyme activity and in the control of insulin receptor activity. High ACP1 activity was positively associated with high glycemic levels and with high body mass index (BMI) values. The MN blood system is a blood group system with three phenotypes each one showing different associations with some diseases, including some related with obesity. Finally, the Lewis System was focused on a single locus with two antigens, Le a and Le b. Confirming this characteristic as a genetic marker of obesity may contribute to the explanation of individual differences in the prevalence of obesity. The group under study involves 85 Portuguese adult women with complete data for all variables, taken from a data base with 714 subjects from the Genetic Laboratory, Centre of Endocrinology and Metabolism of University of Lisbon. The aim of the study is to explore and examine the relationship between the weight categories and the explanatory variables, with emphasis on risk for obesity. Therefore, an ordinal regression model was tried, considering as the regressor variables the Haptoglobin phenotype, Acid phosphatase (ACP1) phenotype, MN blood group system, Lewis system, the enzymatic activity of ACP1, age and some association effects between these factors. Some significant main effects were found at a 5% significance level: the phenotypeLe(a-b+) of Lewis System (p-value=0,021) and age (p-value=0,002). The phenotype Le(a-b+) of Lewis System is associated with a decreased risk for obesity (odds ratio 0,139; CI95%(0,016; 0,754)); age (as expected) is associated with an increased risk for obesity (odds ratio 1,11; CI95%(1,038; 1,190))
- Haptoglobin, acid phosphatase and demographic factors: obesity riskPublication . Ramos, Maria do Rosário; Carolino, Elisabete; Oliveira, Teresa; Silva, A. P.; Carvalho, R.; Bicho, M.The aim of this work is to study the risk of obesity posed by two genetic factors: haptoglobin phenotype and acid phosphatase phenotype, one enzymatic activity: acid phosphatase activity (ACP1), age and gender. Haptoglobin (Hp) is a protein of the immune system, and three phenotypes of Hp are found in humans: Hp1-1, Hp2-1, and Hp2-2. This protein is associated with a susceptibility to common pathological conditions, such as obesity. ACP1 is an intracellular enzyme The phenotypes of ACP1 (AA, AB, AC, BB, BC, CC) are also considered. We took a sample of 127 subjects with complete data from 714 registers. Since we intend to identify risk factors for obesity, an ordinal regression model is adjusted, using the Body Mass Index, BMI, to define weight categories. Haptoglobin phenotype, enzymatic activity of ACP1, acid phosphatase phenotype, age and gender are considered as regressor variables. We found three factors associated with an increased risk of obesity: phenotype Hp2-1 of haptoglobin (estimated odds ratio OR 11.54), phenotype AA of acid phosphatase (OR 33.788) and age (OR 1.39). The interaction between phenotype Hp2-1 and phenotype AC is associated with a decreased risk of obesity (OR 0.032); The interaction between phenotype AA and ACP1 activity is associated with a decreased risk of obesity (OR 0.954).