Browsing by Author "Santos, Isabel A."
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- Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patientsPublication . Nunes, Catarina S.; Ferreira, David A.; Antunes, Luís; Lobo, Francisco; Santos, Isabel A.; Amorim, PedroStudy Objective: To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design: Prospective study. Setting: Operating room. Patients: 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score N 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions: A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL 1 . Main Results: Propofol concentration at LOC was 4.9 ± 1 μg mL 1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μg mL 1 and 3.41 ± 1.5 ng mL 1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions: The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.