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When sex matters: differences in the central nervous system as imaged by OCT through the retina

2023Journal article Open access
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dc.contributor.authorNunes, Ana
dc.contributor.authorSerranho, Pedro
dc.contributor.authorGuimarães, Pedro
dc.contributor.authorFerreira, João
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorBernardes, Rui
dc.date.accessioned2024-09-05T15:12:07Z
dc.date.available2024-09-05T15:12:07Z
dc.date.issued2023
dc.description.abstractBackground: Retinal texture has gained momentum as a source of biomarkers of neurodegeneration, as it is sensitive to subtle differences in the central nervous system from texture analysis of the neuroretina. Sex differences in the retina structure, as detected by layer thickness measurements from optical coherence tomography (OCT) data, have been discussed in the literature. However, the effect of sex on retinal interocular differences in healthy adults has been overlooked and remains largely unreported. Methods: We computed mean value fundus images for the neuroretina layers as imaged by OCT of healthy individuals. Texture metrics were obtained from these images to assess whether women and men have the same retina texture characteristics in both eyes. Texture features were tested for group mean differences between the right and left eye. Results: Corrected texture differences exist only in the female group. Conclusions: This work illustrates that the differences between the right and left eyes manifest differently in females and males. This further supports the need for tight control and minute analysis in studies where interocular asymmetry may be used as a disease biomarker, and the potential of texture analysis applied to OCT imaging to spot differences in the retina.pt_PT
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology (FCT) under UIDP&B/04950/2020 (M.C.-B.) and Ph.D. grant 2020.05578.BD (A.N.).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/jimaging10010006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.2/16526
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationExploring texture biomarkers of neurodegeneration in the retina
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTexture analysispt_PT
dc.subjectNeuroretinapt_PT
dc.subjectCentral nervous systempt_PT
dc.subjectSex differencespt_PT
dc.subjectInterocular asymmetrypt_PT
dc.subjectOptical coherence tomographypt_PT
dc.titleWhen sex matters: differences in the central nervous system as imaged by OCT through the retinapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExploring texture biomarkers of neurodegeneration in the retina
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.05578.BD/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage6pt_PT
oaire.citation.titleJournal of Imagingpt_PT
oaire.citation.volume10pt_PT
person.familyNameNunes
person.familyNameSerranho
person.familyNameGuimarães
person.familyNameCastelo-Branco
person.familyNameDias Cortesão dos Santos Bernardes
person.givenNameAna
person.givenNamePedro
person.givenNamePedro
person.givenNameMiguel
person.givenNameRui Manuel
person.identifier1587486
person.identifierM-4231-2013
person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.ciencia-idC012-547B-1F6A
person.identifier.ciencia-id7A12-48FE-7B56
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.orcid0000-0001-5821-7964
person.identifier.orcid0000-0003-2176-3923
person.identifier.orcid0000-0002-9465-4413
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0002-6677-2754
person.identifier.scopus-author-id56647722300
person.identifier.scopus-author-id7004634386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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