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Sexual dimorphism of the adult human retina assessed by optical coherence tomography

2020Journal article Open access
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dc.contributor.authorNunes, Ana
dc.contributor.authorSerranho, Pedro
dc.contributor.authorQuental, Hugo
dc.contributor.authorAmbrósio, António F.
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorBernardes, Rui
dc.date.accessioned2021-01-21T17:04:33Z
dc.date.available2021-12-31T01:30:20Z
dc.date.issued2020
dc.description.abstractSexual dimorphism in the human visual system is a well-established phenomenon, and recent research has unveiled possible connections between gonadal hormones and the retina status. In the literature, the findings are quite diverse and inconclusive results have been reported as well. In the study herein, texture analysis was applied to computed optical coherence tomography (OCT) fundus images to identify differences between female and male healthy adult controls at the six neuroretinal layers. Furthermore, younger and older groups were formed to assess differences across the adult lifespan. Besides local and global texture features, the thickness of each retinal layer at study was also analysed. The vast majority of the differences between female and male groups were found from the ganglion cell layer (GCL) to the outer plexiform layer (OPL), with the retinal nerve fibre layer (RNFL) layer being the least distinct one. For the sub-study by age, the younger group show similar results as those for the entire population, except for the RNFL. On the other hand, the older group presents minute differences between female and male subjects. These findings suggest that studies should be well balanced by sex, and particular care should be taken in the age span of the study groups. In the present study, we also demonstrate that texture and thickness are independent, for the most part, that thickness conveys the least information, and that texture is a strong candidate biomarker of eye and central nervous system status in health and disease.pt_PT
dc.description.sponsorshipThis study was supported by The Portuguese Foundation for Science and Technology (PEst-ID/NEU/04539/2019) and UID/04950/2017, by FEDER-COMPETE (POCI-01-0145-FEDER-007440 and POCI01-0145-FEDER-16428), and by Centro 2020 FEDERCOMPETE (BIGDATIMAGE, CENTRO-01-0145-FEDER-000016).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12553-020-00428-3pt_PT
dc.identifier.issn2190-7188
dc.identifier.urihttp://hdl.handle.net/10400.2/10432
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectSexual dimorphismpt_PT
dc.subjectRetinapt_PT
dc.subjectOptical coherence tomographypt_PT
dc.subjectTexture analysispt_PT
dc.titleSexual dimorphism of the adult human retina assessed by optical coherence tomographypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage924pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage913pt_PT
oaire.citation.titleHealth and Technologypt_PT
oaire.citation.volume10pt_PT
person.familyNameNunes
person.familyNameSerranho
person.familyNamePereira Quental
person.familyNameAmbrósio
person.familyNameCastelo-Branco
person.familyNameDias Cortesão dos Santos Bernardes
person.givenNameAna
person.givenNamePedro
person.givenNameHugo Alexandre
person.givenNameAntonio F
person.givenNameMiguel
person.givenNameRui Manuel
person.identifier171132
person.identifierM-4231-2013
person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.ciencia-idED19-8244-0AF1
person.identifier.ciencia-id4E11-2573-20FE
person.identifier.ciencia-id7A12-48FE-7B56
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.orcid0000-0001-5821-7964
person.identifier.orcid0000-0003-2176-3923
person.identifier.orcid0000-0001-9504-6543
person.identifier.orcid0000-0002-0477-1641
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0002-6677-2754
person.identifier.scopus-author-id7006302528
person.identifier.scopus-author-id7004634386
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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