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Direct crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulation

2025-04-21Artigo científico Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Médica
dc.contributor.authorJordão, João
dc.contributor.authorFigueira, João
dc.contributor.authorMorgado, António Miguel
dc.contributor.authorGuimarães, Pedro
dc.contributor.authorSerranho, Pedro
dc.contributor.authorCastro-Farías, Daniela
dc.contributor.authorDeBuc, Delia Cabrera
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorPaques, Michel
dc.contributor.authorBernardes, Rui
dc.date.accessioned2026-01-05T12:40:33Z
dc.date.available2026-01-05T12:40:33Z
dc.date.issued2025-04-21
dc.description.abstractCrosstalk mechanisms between retinas were never documented in humans despite being documented for several other species, including non-human primates. Results of the first-in-human study that documents the crosstalk between retinas by measuring the vascular response in one retina to the photic stimulation of the contralateral eye in health and disease are reported herein. A stimulation apparatus was developed and integrated into an adaptive-optics fundus camera to image 32 healthy control (HC) subjects and 20 type 1 diabetes mellitus (DM) patients. Ipsilateral and contralateral neurovascular coupling effects were documented, and criteria were established to consider an actual response and find positive and negative responses. Ten (31.2%) and two (6.2%) subjects of the HC group presented contralateral positive and negative responses, respectively, and three (15.0%) positive and four (20.0%) negative responses were found for the DM group. Also, statistically significant differences in the ipsilateral (p < 0.001) and contralateral (p = 0.027) responses were found for the HC group, rejecting the null (non-response) hypothesis. This finding raises the need to revisit the current knowledge of neurovascular coupling mechanisms and the association between its dysregulation and neurological disorders. Further studies involving distinct populations and imaging centers are necessary to validate the findings herein.
dc.description.sponsorshipThis study was supported by The Portuguese Foundation for Science and Technology (FCT) through the 2022.07585.PTDC project (DOI:https://doi.org/10.54499/2022.07585.PTDC), UI/BD/154285/2022 (Ph.D. grant), FCT/UIDB/4950/Base/2020 (DOI:https://doi.org/10.54499/UIDB/04950/2020), FCT/UIDP/4950/Programatico/2020 (DOI:https://doi.org/10.54499/UIDP/04950/2020), FCT/UIDB/4950/Base/2025 and FCT/UIDP/4950/Programatico/2025.
dc.identifier.citationJordão, J., Figueira, J., Morgado, M. et al. Direct crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulation. Sci Rep 15, 13684 (2025). https://doi.org/10.1038/s41598-025-98631-7
dc.identifier.doi10.1038/s41598-025-98631-7
dc.identifier.other40258943
dc.identifier.urihttp://hdl.handle.net/10400.2/20625
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Research
dc.relationMechanism underlying neurovascular coupling in the retina
dc.relationCoimbra Institute for Biomedical Imaging and Translational Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCentral nervous system
dc.subjectCirculation
dc.subjectFlicker-induced hyperemia
dc.subjectFunctional imaging
dc.subjectNeurovascular coupling
dc.subjectRetina
dc.titleDirect crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMechanism underlying neurovascular coupling in the retina
oaire.awardTitleCoimbra Institute for Biomedical Imaging and Translational Research
oaire.awardURIhttp://hdl.handle.net/10400.2/20624
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04950%2F2020/PT
oaire.citation.titleScientific Reports
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMorgado
person.familyNameGuimarães
person.familyNameSerranho
person.familyNameCastelo-Branco
person.familyNameBernardes
person.givenNameAntónio Miguel
person.givenNamePedro
person.givenNamePedro
person.givenNameMiguel
person.givenNameRui
person.identifier1587486
person.identifierM-4231-2013
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person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.ciencia-id7A12-48FE-7B56
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.orcid0000-0001-9455-1206
person.identifier.orcid0000-0002-9465-4413
person.identifier.orcid0000-0003-2176-3923
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0002-6677-2754
person.identifier.scopus-author-id7003522858
person.identifier.scopus-author-id56647722300
person.identifier.scopus-author-id7004634386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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