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Modelling drugs' pharmacodynamic interaction during general anaesthesia: the choice of pharmacokinetic model

2006Book part Open access
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dc.contributor.authorNunes, Catarina S.
dc.contributor.authorMendonça, Teresa F.
dc.contributor.authorAntunes, Luís
dc.contributor.authorFerreira, David A.
dc.contributor.authorLobo, Francisco
dc.contributor.authorAmorim, Pedro
dc.date.accessioned2023-05-25T14:12:20Z
dc.date.available2023-05-25T14:12:20Z
dc.date.issued2006
dc.description.abstractThe effect of drugs’ interaction on the brain signal Bispectral Index (BIS) is of great importance for an anaesthesia control drug infusion system. In this study, two renowned pharmacokinetic (PK) models for propofol are compared, in order to evaluate its influence on the performance/predictably of a drug interaction model for BIS, considering data of 45 patients. The model was fitted per patient during anaesthesia induction, and tested for prediction under surgery. The results showed that the choice of PK model had influence on the overall performance. In the prediction phase, only one PK model presented good results with small errors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes, C.S., T. Mendonça, L. Antunes, D. Ferreira, F. Lobo, and P. Amorim (2006) Modelling drugs' pharmacodynamic interaction during general anaesthesia: the choice of pharmacokinetic model. IFAC Proceedings Volumes, 39(18), p. 447-452.pt_PT
dc.identifier.doi10.3182/20060920-3-FR-2912.00080pt_PT
dc.identifier.isbn9783902661180
dc.identifier.issn1474-6670
dc.identifier.urihttp://hdl.handle.net/10400.2/13852
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1474667015329980?via%3Dihubpt_PT
dc.subjectPharmacokinetic datapt_PT
dc.subjectModellingpt_PT
dc.subjectBiomedical systemspt_PT
dc.subjectPredictionpt_PT
dc.titleModelling drugs' pharmacodynamic interaction during general anaesthesia: the choice of pharmacokinetic modelpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POSC/POSC%2FEEA-SRI%2F57607%2F2004/PT
oaire.citation.endPage452pt_PT
oaire.citation.issue18pt_PT
oaire.citation.startPage447pt_PT
oaire.citation.titleIFAC Proceedings Volumespt_PT
oaire.citation.volume39pt_PT
oaire.fundingStreamPOSC
person.familyNameDa Costa Nunes Duarte
person.familyNameAmorim
person.givenNameCatarina Sofia
person.givenNamePedro
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0002-8357-0994
person.identifier.orcid0000-0001-7466-4174
person.identifier.scopus-author-id55429654100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typebookPartpt_PT
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relation.isAuthorOfPublication1ef321dd-4f09-493c-b801-e9a99b28947d
relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b
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