Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties

This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(μ6-sdba)]n (1) and [Cu(μ4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4′-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymerfilms based on agarose (AGR) or potato starch (PS) as model polysaccharide biopolymers with varying rates of degradability and silver/copper release. BioCPs and derived biopolymer films (1@[AGR]n, 2@[AGR]n, 1@[PS]n, and 2@[PS]n) with a low loading of dopant (1–5 wt%) show promising antibacterial activity against Gram-positive (S. aureus and S. epidermidis) and Gram-negative (E. coli and P. aeruginosa) bacteria. Silver doped biopolymer films also totally impair the formation of bacterial biofilms, with undetectable biofilm cells in several cases (∼7.5 log or 99.99999% inhibition). By reporting new bioCPs and biopolymer films obtained from renewable polysaccharides, this multidisciplinary work extends the application of coordination compounds as components of hybrid functional materials with antimicrobial properties and prospective biomedical relevance.

URI

http://hdl.handle.net/10400.2/19821

Citation

Tiago A. Fernandes, Filipa Macedo, Rafaela G. Cabral, Telma Guiu, Chris H. J. Franco, Paula Jorge, Ana Catarina Sousa, Vânia André, Nuno Cerca, Alexander M. Kirillov, Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties, RSC Appl. Interfaces, 2024,1, 98-109. Advance Article. http://doi.org/10.1039/d3lf00123g