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The influence of two different drug infusion profiles on the pharmacodynamics model performance

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dc.contributor.authorFerreira, Ana Isabel Leitão
dc.contributor.authorNunes, Catarina S.
dc.contributor.authorGabriel, J.
dc.contributor.authorAmorim, Pedro
dc.date.accessioned2022-01-20T17:14:27Z
dc.date.available2022-01-20T17:14:27Z
dc.date.issued2015
dc.description.abstractTo model the effect of anesthetic drugs on the Bispectral Index (BIS) of the EEG is of great importance for a reliable predictive response model during surgery. In this study, the impact of using two different drug infusion profiles in a pharmacodynamics interaction model was studied and the methods were compared with respect to their performance. Clinical data of 22 patients were considered. The interaction model was optimized per patient using nonlinear least squares during the induction of anesthesia, and tested for prediction abilities of test patients. In the optimization phase, all models could follow the BIS trend with errors not significantly differ- ent from zero. In the test data the choice of drug infusion pro- file proved to have a significant impact, showing that the per- formance is greatly influenced by the interaction. Results also show a time delay between the BIS signal and the Modeled BIS in both groups. This delay corresponds to a delay in the dy- namics of the patient and could be related to the delay in BIS processing time. This work is an important step to predict the effect of anesthetic drugs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira A.L., Nunes C.S., Gabriel J., Amorim P. (2015) The influence of two different drug infusion profiles on the pharmacodynamics model performance. In: Jaffray D. (eds) World Congress on Medical Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada. IFMBE Proceedings, vol 51. Springer, Cham.pt_PT
dc.identifier.doi10.1007/978-3-319-19387-8_214pt_PT
dc.identifier.isbn978-3-319-19386-1
dc.identifier.urihttp://hdl.handle.net/10400.2/11664
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectBispectral indexpt_PT
dc.subjectPharmacokinetic modelspt_PT
dc.subjectInteraction modellingpt_PT
dc.titleThe influence of two different drug infusion profiles on the pharmacodynamics model performancept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage880pt_PT
oaire.citation.startPage874pt_PT
oaire.citation.titleWorld Congress on Medical Physics and Biomedical Engineeringpt_PT
oaire.citation.volume51pt_PT
person.familyNameFerreira
person.familyNameNunes
person.familyNameAmorim
person.givenNameAna
person.givenNameCatarina S.
person.givenNamePedro
person.identifier.ciencia-id791E-88E5-5BD7
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0003-2350-6947
person.identifier.orcid0000-0002-8357-0994
person.identifier.orcid0000-0001-7466-4174
person.identifier.ridH-8140-2014
person.identifier.scopus-author-id57204246003
person.identifier.scopus-author-id55429654100
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicatione49bed16-c1ae-4be4-9950-a01d09284de0
relation.isAuthorOfPublicationcc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isAuthorOfPublication1ef321dd-4f09-493c-b801-e9a99b28947d
relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b

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