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Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

2021Journal article Open access
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dc.contributor.authorFerreira, Hugo
dc.contributor.authorMartins, João
dc.contributor.authorMoreira, Paula I.
dc.contributor.authorAmbrósio, António F.
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorSerranho, Pedro
dc.contributor.authorBernardes, Rui
dc.date.accessioned2022-01-05T12:22:12Z
dc.date.available2022-01-05T12:22:12Z
dc.date.issued2021
dc.description.abstractMice are widely used as models for many diseases, including eye and neurodegenerative diseases. However, there is a lack of normative data for retinal thickness over time, especially at young ages. In this work, we present a normative thickness database from one to four-months-old, for nine layers/layer-aggregates, including the total retinal thickness, obtained from the segmentation of spectral-domain optical coherence tomography (SD-OCT) data from the C57BL6/129S mouse strain. Based on fifty-seven mice, this normative database provides an opportunity to study the ageing of control mice and characterize disease models' ageing, such as the triple transgenic mouse model of Alzheimer's disease (3×Tg-AD) used in this work. We report thickness measurements, the differences in thickness per layer, demonstrate a nasal-temporal asymmetry, and the variation of thickness as a function to the distance to the optic disc center. Significant differences were found between the transgenic group's thickness and the normative database for the entire period covered in this study. Even though it is well accepted that retinal nerve fiber layer (RNFL) thinning is a hallmark of neurodegeneration, our results show a thicker RNFL-GCL (RNFL-Ganglion cell layer) aggregate for the 3×Tg-AD mice until four-months-old.pt_PT
dc.description.sponsorshipThis study was supported by The Portuguese Foundation for Science and Technology (FCT) through PTDC/ EMD-EMD/28039/2017, UIDB/04950/2020, Pest-UID/ NEU/04539/2019, and by FEDER-COMPETE through POCI-01-0145-FEDER-028039.pt_PT
dc.description.sponsorshipPest-UID/NEU/04539/2019 e POCI-01-0145-FEDER-028039
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.18632/aging.202916pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.2/11603
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCoimbra Institute for Biomedical Imaging and Translational Research
dc.subjectOptical coherence tomographypt_PT
dc.subjectNormative datapt_PT
dc.subjectAlzheimer's diseasept_PT
dc.subjectMouse modelpt_PT
dc.subjectRetinal thicknesspt_PT
dc.titleLongitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCoimbra Institute for Biomedical Imaging and Translational Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMD-EMD%2F28039%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04950%2F2020/PT
oaire.citation.endPage9454pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage9433pt_PT
oaire.citation.titleAgingpt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAmbrósio
person.familyNameCastelo-Branco
person.familyNameSerranho
person.familyNameDias Cortesão dos Santos Bernardes
person.givenNameAntonio F
person.givenNameMiguel
person.givenNamePedro
person.givenNameRui Manuel
person.identifier171132
person.identifierM-4231-2013
person.identifier.ciencia-id4E11-2573-20FE
person.identifier.ciencia-id7A12-48FE-7B56
person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.orcid0000-0002-0477-1641
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0003-2176-3923
person.identifier.orcid0000-0002-6677-2754
person.identifier.scopus-author-id7006302528
person.identifier.scopus-author-id7004634386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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