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Noninvasive evaluation of retinal leakage using optical coherence tomography

2011Journal article Open access
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dc.contributor.authorBernardes, Rui
dc.contributor.authorSantos, Torcato
dc.contributor.authorSerranho, Pedro
dc.contributor.authorLobo, Conceição
dc.contributor.authorCunha-Vaz, José
dc.date.accessioned2011-11-11T10:34:10Z
dc.date.available2011-11-11T10:34:10Z
dc.date.issued2011
dc.description.abstractPurpose: To demonstrate the association between changes in the blood-retinal barrier (BRB) identified by fluorescein leakage and those in the optical properties of the human retina determined by optical coherence tomography (OCT) and show how these changes can be quantified and their location identified within the retina. Methods: Two imaging techniques were applied: the retinal leakage analyzer, to map BRB function into intact or disrupted regions, and OCT, to measure refractive index changes along the light path within the human ocular fundus. Results: A total of 140 comparisons were made, 77 between areas of regions receiving the same classification (intact or disrupted BRB) and 63 between areas of regions receiving distinct classifications, from 4 pathological cases: 2 eyes with nonproliferative diabetic retinopathy and 2 eyes with wet age-related macular degeneration. In all cases, the distribution of OCT data between regions of intact and regions of disrupted BRB, identified by the retinal leakage analyzer, was quantified and was statistically significantly different (p < 0.001). In addition, it was found that the differences could be localized in the retina to specific structural sequences. Conclusions: Using a novel method to analyze OCT data, we showed that it may be possible to quantify differences in the extracellular compartment in eyes with retinal disease and alterations of the BRB. Based on quantitative techniques, our findings demonstrate the presence of indirect information on the BRB status within noninvasive OCT data.por
dc.description.sponsorshipFundação para a Ciência e Tecnologiapor
dc.description.sponsorshipFEDER
dc.description.sponsorshipPrograma Compete
dc.identifier.citationBernardes, Rui et al. - Noninvasive evaluation of retinal leakage using optical coherence tomography. "Ophthalmologica" [Em linha]. ISSN 0030-3755. Vol. 226, nº 2 (Jul. 2011), p. 29-36por
dc.identifier.issn0030-3755
dc.identifier.urihttp://hdl.handle.net/10400.2/1955
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.ispartofseries226
dc.relation.publisherversionhttp://content.karger.com/ProdukteDB/produkte.asp?por
dc.relation.publisherversiondoi=10.1159/000326268
dc.subjectOptical coherence tomographypor
dc.subjectRetinal leakage analyzerpor
dc.subjectFluorescein angiographypor
dc.subjectBlood-retinal barrierpor
dc.titleNoninvasive evaluation of retinal leakage using optical coherence tomographypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage36por
oaire.citation.startPage29por
oaire.citation.titleOphthalmologicapor
person.familyNameDias Cortesão dos Santos Bernardes
person.familyNameSerranho
person.givenNameRui Manuel
person.givenNamePedro
person.identifierM-4231-2013
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.orcid0000-0002-6677-2754
person.identifier.orcid0000-0003-2176-3923
person.identifier.scopus-author-id7004634386
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublicationc7f6eb4c-c743-4b38-83f5-70796c0851ca
relation.isAuthorOfPublication.latestForDiscoveryc7f6eb4c-c743-4b38-83f5-70796c0851ca

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