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Feedforward adaptive control of the Bispectral Index of the EEG using the intravenous anaesthetic drug propofol

2008Journal article Restricted access
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dc.contributor.authorNunes, Catarina S.
dc.contributor.authorMendonça, Teresa
dc.contributor.authorLemos, João M.
dc.contributor.authorAmorim, Pedro
dc.date.accessioned2023-05-25T15:23:57Z
dc.date.available2023-05-25T15:23:57Z
dc.date.issued2008
dc.description.abstractThe problem of controlling the level of unconsciousness measured by the Bispectral Index (BIS) of the EEG of patients under anaesthesia is considered. The manipulated variable is the infusion rate of the hypnotic drug propofol. In order to tackle the high uncertainties present in the system, the predictive adaptive controller MUSMAR is used. The performance of the controller is illustrated by means of simulations with 50 patient individual adjusted models (nonlinear models), which incorporate the effect of the drugs interaction on BIS. This work presents a feasibility study of the control of the BIS exploring the above ideas. These results show that such a control structure can be adequate to control the BIS signal during total intravenous anaesthesia. The controller was able to adequately achieve and maintain the BIS signal with different patient dynamics, reference values and noise. A major challenge for the automation of anaesthesia consists of replicating the experience of the anaesthetist. Clearly, this calls for the use of feedforward from measurable signals correlated with disturbances (e.g. electromyography—EMG, analgesic drug). The results also show that the analgesic and EMG have different influences on the performance and therefore carry different but relevant information.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes, C.S., Mendonça, T., Lemos, J.M. and Amorim, P. (2009), Feedforward adaptive control of the Bispectral Index of the EEG using the intravenous anaesthetic drug propofol. Int. J. Adapt. Control Signal Process., 23: 485-503.pt_PT
dc.identifier.doi10.1002/acs.1097pt_PT
dc.identifier.issn1099-1115
dc.identifier.urihttp://hdl.handle.net/10400.2/13856
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons Ltdpt_PT
dc.subjectPredictive adaptive controlpt_PT
dc.subjectMUSMARpt_PT
dc.subjectFeedforward actionpt_PT
dc.subjectBispectral Indexpt_PT
dc.subjectAnaesthesiapt_PT
dc.subjectDrug deliverypt_PT
dc.titleFeedforward adaptive control of the Bispectral Index of the EEG using the intravenous anaesthetic drug propofolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEEA-ACR%2F69288%2F2006/PT
oaire.citation.endPage503pt_PT
oaire.citation.issue23pt_PT
oaire.citation.startPage485pt_PT
oaire.citation.titleInternational Journal of Adaptive Control and Signal Processingpt_PT
oaire.fundingStream3599-PPCDT
person.familyNameDa Costa Nunes Duarte
person.familyNameAmorim
person.givenNameCatarina Sofia
person.givenNamePedro
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0002-8357-0994
person.identifier.orcid0000-0001-7466-4174
person.identifier.scopus-author-id55429654100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1ef321dd-4f09-493c-b801-e9a99b28947d
relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isProjectOfPublicationcc100042-6845-482a-8306-8eb06c66e0bb
relation.isProjectOfPublication.latestForDiscoverycc100042-6845-482a-8306-8eb06c66e0bb

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