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Acid phosphatase, some genetic polymorphism and obesity risk factors in adult women

2010Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidadept_PT
dc.contributor.authorCarolino, E.
dc.contributor.authorOliveira, T.
dc.contributor.authorSilva, A. P.
dc.contributor.authorCarvalho, R
dc.contributor.authorBicho, M.
dc.date.accessioned2023-08-03T14:15:55Z
dc.date.available2023-08-03T14:15:55Z
dc.date.issued2010
dc.description.abstractRecent works point out to a relation between some genetic factors and the predisposition for obesity. We believe, therefore, to be relevant to conduct this kind of study in the Portuguese population. In the present work the following genetic factors are considered: Haptoglobin phenotype, the Acid Phosphatasehenotype and two blood group systems, the MN System and the Lewis System. In addition, it was also considered one demographic factor, age, and one enzymatic activity, the Acid Phosphatase Activity. Haptoglobin (Hp) is a hemoglobin-binding protein of the immune system expressed by a genetic polymorphism with three major phenotypes. This protein is associated in some works with susceptibility for common pathological situations, such as some disorders related with obesity. The Acid phosphatase, more precisely the Acid phosphatase locus 1 (ACP1), is a highly polymorphic enzyme that has an important role in flavoenzyme activity and in the control of insulin receptor activity. High ACP1 activity was positively associated with high glycemic levels and with high body mass index (BMI) values. The MN blood system is a blood group system with three phenotypes each one showing different associations with some diseases, including some related with obesity. Finally, the Lewis System was focused on a single locus with two antigens, Le a and Le b. Confirming this characteristic as a genetic marker of obesity may contribute to the explanation of individual differences in the prevalence of obesity. The group under study involves 85 Portuguese adult women with complete data for all variables, taken from a data base with 714 subjects from the Genetic Laboratory, Centre of Endocrinology and Metabolism of University of Lisbon. The aim of the study is to explore and examine the relationship between the weight categories and the explanatory variables, with emphasis on risk for obesity. Therefore, an ordinal regression model was tried, considering as the regressor variables the Haptoglobin phenotype, Acid phosphatase (ACP1) phenotype, MN blood group system, Lewis system, the enzymatic activity of ACP1, age and some association effects between these factors. Some significant main effects were found at a 5% significance level: the phenotypeLe(a-b+) of Lewis System (p-value=0,021) and age (p-value=0,002). The phenotype Le(a-b+) of Lewis System is associated with a decreased risk for obesity (odds ratio 0,139; CI95%(0,016; 0,754)); age (as expected) is associated with an increased risk for obesity (odds ratio 1,11; CI95%(1,038; 1,190))pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationE. Carolino, M. R. Ramos, T. Oliveira, A. P. Silva, R. Carvalho, M. Bicho (2010) Acid Phosphatase, Some Genetic Polimorphism and obesity risk factors in adult women. (2010) Portuguese Journal of Quantitative Methods, Volume 1, issue II, pp. 29-37, Ed. Silabopt_PT
dc.identifier.isbn9771647798025
dc.identifier.urihttp://hdl.handle.net/10400.2/14729
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSilabopt_PT
dc.relation.publisherversionhttps://silabo.pt/catalogo/ciencias-exatas-e-naturais/estatistica/livro/portuguese-journal-of-quantitative-methods-vol-1-ii/pt_PT
dc.subjectObesitypt_PT
dc.subjectLewis blood grouppt_PT
dc.subjectMN blood grouppt_PT
dc.subjectOrdinal regressionpt_PT
dc.subjectProbitpt_PT
dc.subjectOdds ratiopt_PT
dc.titleAcid phosphatase, some genetic polymorphism and obesity risk factors in adult womenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePortuguese Journal of Quantitative Methodspt_PT
oaire.citation.volume1pt_PT
person.familyNameRamos
person.familyNameOliveira
person.givenNameMaria do Rosário
person.givenNameTeresa A.
person.identifier206757
person.identifier1155497
person.identifier.ciencia-id3A1F-E648-078D
person.identifier.ciencia-id8814-A54B-12DE
person.identifier.orcid0000-0001-9114-0807
person.identifier.orcid0000-0003-3283-9946
person.identifier.ridP-4530-2015
person.identifier.ridJ-3077-2019
person.identifier.scopus-author-id54403639500
person.identifier.scopus-author-id54403540300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc6cdb7b7-607d-4775-947f-d153ff6dded2
relation.isAuthorOfPublication82b3cd70-88cc-4d31-b4b0-4705f8496c67
relation.isAuthorOfPublication.latestForDiscoveryc6cdb7b7-607d-4775-947f-d153ff6dded2

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