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Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease

2020Journal article Open access
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dc.contributor.authorFerreira, Hugo
dc.contributor.authorMartins, João
dc.contributor.authorNunes, Ana
dc.contributor.authorMoreira, Paula I.
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorAmbrósio, António F.
dc.contributor.authorSerranho, Pedro
dc.contributor.authorBernardes, Rui
dc.date.accessioned2021-03-01T11:44:44Z
dc.date.available2021-12-31T01:30:20Z
dc.date.issued2020
dc.description.abstractAlzheimer’s disease (AD) is a progressive neurodegenerative disorder whose diagnosis remains a notable challenge. The literature suggests that cerebral changes precede AD symptoms by over two decades, implying a significantly advanced stage of AD by the time it is usually diagnosed. In the study herein, texture analysis was applied to computed optical coherence tomography ocular fundus images to identify differences between a group of the transgenic mouse model of the Alzheimer’s disease (3×Tg-AD) and a group of wild-type mice, at the ages of one and two-months-old. A substantial difference between groups was found at both time-points across all neuroretina’s layers. Here, the inner nuclear layer stands out both in the level of statistically significant differences and on the extension of these differences which span through the imaged area. Also, the progression of AD is suggested to be spotted by texture analysis as demonstrated by the significant difference found in the inner plexiform and the outer nuclear layers from the age of one to the age of two-months-old. These findings demonstrate the potential of the use of the retina and texture analysis to the diagnosis of AD and monitor AD progression. Besides, the differences between groups found in this study suggest that the 3×Tg-AD model may be inappropriate to study early changes associated with the AD and other animal models should be tested following the same path and rationale. Moreover, these results also suggest that the human genes present in these transgenic mice may have an impact on the neurodevelopment of offspring which would justify the significant changes found at the age of one-month-old.pt_PT
dc.description.sponsorshipThis study was funded by The Portuguese Foundation for Science and Technology (FCT) throught PTDC/EMD-EMD/28039/2017, PEst-UID/NEU/04539/2019, UID/Multi/04621/2013 and UID/04950/2017, and by FEDER-COMPETE through POCI-01-0145-FEDER-028039 and POCI-01-0145-FEDER-007440.pt_PT
dc.description.sponsorshipThis study was funded by The Portuguese Foundation for Science and Technology (FCT) throught PTDC/EMD-EMD/28039/2017, PEst-UID/NEU/04539/2019, UID/Multi/04621/2013 and UID/04950/2017, and by FEDER-COMPETE through POCI-01-0145-FEDER-028039 and POCI-01-0145-FEDER-007440.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12553-020-00413-wpt_PT
dc.identifier.issn2190-7188
dc.identifier.urihttp://hdl.handle.net/10400.2/10530
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectOptical coherence tomographypt_PT
dc.subjectRetinapt_PT
dc.subjectBiomarkerspt_PT
dc.subjectTexture analysispt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectMouse modelpt_PT
dc.subject3×Tg-ADpt_PT
dc.subjectEarly diagnosispt_PT
dc.titleCharacterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMD-EMD%2F28039%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04621%2F2013/PT
oaire.citation.endPage883pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage875pt_PT
oaire.citation.titleHealth and Technologypt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream5876
person.familyNameNunes
person.familyNameCastelo-Branco
person.familyNameAmbrósio
person.familyNameSerranho
person.familyNameDias Cortesão dos Santos Bernardes
person.givenNameAna
person.givenNameMiguel
person.givenNameAntonio F
person.givenNamePedro
person.givenNameRui Manuel
person.identifier171132
person.identifierM-4231-2013
person.identifier.ciencia-id7A12-48FE-7B56
person.identifier.ciencia-id4E11-2573-20FE
person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.orcid0000-0001-5821-7964
person.identifier.orcid0000-0003-4364-6373
person.identifier.orcid0000-0002-0477-1641
person.identifier.orcid0000-0003-2176-3923
person.identifier.orcid0000-0002-6677-2754
person.identifier.scopus-author-id7006302528
person.identifier.scopus-author-id7004634386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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