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Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease

2023Journal article Open access
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dc.contributor.authorBatista, Ana
dc.contributor.authorGuimarães, Pedro
dc.contributor.authorMartins, João
dc.contributor.authorMoreira, Paula I.
dc.contributor.authorAmbrósio, António F.
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorSerranho, Pedro
dc.contributor.authorBernardes, Rui
dc.date.accessioned2024-09-12T16:14:38Z
dc.date.available2024-09-12T16:14:38Z
dc.date.issued2023
dc.description.abstractAnimal models of disease are paramount to understand retinal development, the pathophysiology of eye diseases, and to study neurodegeneration using optical coherence tomography (OCT) data. In this study, we present a comprehensive normative database of retinal thickness in C57BL6/129S mice using spectral-domain OCT data. The database covers a longitudinal period of 16 months, from 1 to 16 months of age, and provides valuable insights into retinal development and changes over time. Our findings reveal that total retinal thickness decreases with age, while the thickness of individual retinal layers and layer aggregates changes in different ways. For example, the outer plexiform layer (OPL), photoreceptor inner segments (ILS), and retinal pigment epithelium (RPE) thickened over time, whereas other retinal layers and layer aggregates became thinner. Additionally, we compare the retinal thickness of wild-type (WT) mice with an animal model of Alzheimer's disease (3×Tg-AD) and show that the transgenic mice exhibit a decrease in total retinal thickness compared to age-matched WT mice, with statistically significant differences observed at all evaluated ages. This normative database of retinal thickness in mice will serve as a reference for future studies on retinal changes in neurodegenerative and eye diseases and will further our understanding of the pathophysiology of these conditions.pt_PT
dc.description.sponsorshipThe authors would like to acknowledge the support by the Portuguese Foundation for Science and Technology (FCT) through PTDC/EMD-EMD/28039/2017, FCT/UIDB/4950/Base/2020 and FCT/UIDP/4950/Programatico/2020, Pest-UID/NEU/04539/2019, and by FEDER-COMPETE through POCI-01-0145-FEDER-028039.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fnagi.2023.1161847pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.2/16550
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOptical coherence tomographypt_PT
dc.subjectRretinal thicknesspt_PT
dc.subjectNormative datapt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subject3×Tg-AD animal modelpt_PT
dc.titleNormative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMD-EMD%2F28039%2F2017/PT
oaire.citation.titleFrontiers in Aging Neurosciencept_PT
oaire.citation.volume15pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameGuimarães
person.familyNameAmbrósio
person.familyNameSerranho
person.familyNameDias Cortesão dos Santos Bernardes
person.givenNamePedro
person.givenNameAntonio F
person.givenNamePedro
person.givenNameRui Manuel
person.identifier1587486
person.identifier171132
person.identifierM-4231-2013
person.identifier.ciencia-idC012-547B-1F6A
person.identifier.ciencia-id4E11-2573-20FE
person.identifier.ciencia-id031F-5D62-E6EC
person.identifier.ciencia-idDB19-B18E-690C
person.identifier.orcid0000-0002-9465-4413
person.identifier.orcid0000-0002-0477-1641
person.identifier.orcid0000-0003-2176-3923
person.identifier.orcid0000-0002-6677-2754
person.identifier.scopus-author-id56647722300
person.identifier.scopus-author-id7006302528
person.identifier.scopus-author-id7004634386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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