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Effect of propofol and remifentanil on a somatosensory evoked potential indicator of pain perception intensity in volunteers

2015-10Journal article Restricted access
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dc.contributor.authorCastro, Ana
dc.contributor.authorAmorim, Pedro
dc.contributor.authorNunes, Catarina S.
dc.contributor.authorAlmeida, Fernando Gomes de
dc.date.accessioned2021-11-30T17:02:55Z
dc.date.available2021-11-30T17:02:55Z
dc.date.issued2015-10
dc.description.abstractSomatosensory evoked potentials (SEPs) have been linked to noxious activation and stimulus intensity. In this exploratory study we investigated the impact of anaesthetic drugs on SEPs and pain ratings, to assess their applicability as an objective measure of the nociception/anti-nociception balance. Following institutional approval and written informed consent, 10 healthy adult volunteers were enrolled (29.5 ± 9.1 years, 63.0 ± 8.9 kg and 171.4 ± 7.2). Median nerve electrical stimulation was adjusted according to volunteers' sensitive, motor and painful thresholds (PT). Baseline SEPs were registered, and remifentanil and propofol administered using a stair scheme TCI. For each drug combination a 1.3×PT stimulus was administered, and volunteers evaluated pain intensity in a numerical rating scale (0-10). SEPs' amplitudes and latencies were normalized by the baseline values, reducing volunteers' intervariability. Stimulation currents varied between 6-52 mA (1.3×PT) and pain ratings between 0 and 9. Cortical SEPs latencies were decreased for higher stimulus intensities (P < 0.01), accompanied by increased pain ratings (P < 0.01). An individually adjusted/normalized ratio based on cortical SEPs amplitude and interpeak latency is proposed([Formula: see text]): [Formula: see text] and NSR were significantly correlated in three out of nine subjects, and [Formula: see text] and remifentanil Ce were significantly correlated in two (low number of evaluation points). [Formula: see text] was shown to decrease with increasing doses of propofol and remifentanil (P < 0.05). The proposed metric was depressed by anaesthetics and reflected pain evaluations. Further research is necessary to increase the number of volunteers and drugs' combination, to assess its applicability during surgically adequate anesthetic leves.pt_PT
dc.description.sponsorshipThe authors would like to thank the participation of all volunteers and clinical investigators in this study, especially Dr. Francisco Lobo, Dr. Liliana Pinto, Dr. Diana Afonso, Dr. Germano Cardoso, Dr. Helena and Dr. Luı´s Silva (Neurinbloc). The first author was supported by a scholarship from the Portuguese Foundation for Science and Technology (FCT - SFRH/BD/35879/2007). The authors would also like to acknowledge the UISPA-IDMEC Porto.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCastro, A., Amorim, P., Nunes, C.S. et al. Effect of propofol and remifentanil on a somatosensory evoked potential indicator of pain perception intensity in volunteers. J Clin Monit Comput 29, 561–567 (2015).pt_PT
dc.identifier.doi10.1007/s10877-014-9632-0pt_PT
dc.identifier.eissn1573-2614
dc.identifier.issn1387-1307
dc.identifier.urihttp://hdl.handle.net/10400.2/11448
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationANÁLISE E CONTROLO DO NÍVEL DE NOCICEPÇÃO DURANTE A ANESTESIA NOCICEPTION LEVEL DURING ANAESTHESIA – ANALYSIS AND CONTROL
dc.subjectAdultpt_PT
dc.subjectDose-response relationshippt_PT
dc.subjectEvoked potentialspt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectHypnotics and Sedativespt_PT
dc.subjectMalept_PT
dc.subjectPain measurementpt_PT
dc.subjectPain perceptionpt_PT
dc.subjectPiperidinespt_PT
dc.subjectPropofolpt_PT
dc.subjectRemifentanilpt_PT
dc.subjectReproducibility of resultspt_PT
dc.subjectSensitivity and specificitypt_PT
dc.subjectDrugpt_PT
dc.subjectSomatosensorypt_PT
dc.titleEffect of propofol and remifentanil on a somatosensory evoked potential indicator of pain perception intensity in volunteerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleANÁLISE E CONTROLO DO NÍVEL DE NOCICEPÇÃO DURANTE A ANESTESIA NOCICEPTION LEVEL DURING ANAESTHESIA – ANALYSIS AND CONTROL
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F35879%2F2007/PT
oaire.citation.endPage567pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage561pt_PT
oaire.citation.titleJournal of Clinical Monitoring and Computingpt_PT
oaire.citation.volume29pt_PT
person.familyNameAmorim
person.familyNameNunes
person.givenNamePedro
person.givenNameCatarina S.
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0001-7466-4174
person.identifier.orcid0000-0002-8357-0994
person.identifier.scopus-author-id55429654100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ef321dd-4f09-493c-b801-e9a99b28947d
relation.isAuthorOfPublicationcc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isProjectOfPublication39b0d927-00b9-4da5-994b-f61021bff202
relation.isProjectOfPublication.latestForDiscovery39b0d927-00b9-4da5-994b-f61021bff202

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