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Brain tumors may alter the relationship between bispectral index values and propofol concentrations during induction of anesthesia

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dc.contributor.authorFerreira, David A.
dc.contributor.authorNunes, Catarina S.
dc.contributor.authorLobo, Francisco
dc.contributor.authorCasal, Manuela
dc.contributor.authorAntunes, Luís M.
dc.contributor.authorAmorim, Pedro
dc.date.accessioned2023-05-29T15:40:39Z
dc.date.available2023-05-29T15:40:39Z
dc.date.issued2008
dc.description.abstractStudy Objective: To compare propofol-predicted effect-site concentrations (PropCe) and bispectral index (BIS) of the electroencephalogram during induction of anesthesia in patients with small brain tumors and to analyze BIS and PropCe at loss of consciousness (LOC). Design: Prospective investigation. Setting: Operating theater of a university hospital. Patients: 26 ASA physical status I and II patients, 13 of whom were scheduled for nontumor spinal surgeries, and the other 13, for brain surgery for small brain tumor removal. Interventions: Anesthesia was induced with a propofol 1% constant infusion rate of 200 mL/h until LOC. Measurements: BIS, PropCe, heart rate, and mean arterial pressure were analyzed at the beginning of the propofol infusion and every 30 seconds during induction. Main Results: The BIS values were significantly higher in patients with brain tumors in the period from 150 to 210 seconds, with PropCe similar to patients without brain tumors. Loss of consciousness occurred 3.6 ± 0.8 minutes in patients without brain tumors and 3.9 ± 0.7 minutes in patients with brain tumors. No differences were observed between groups in the time to LOC (3.6 ± 0.8 in group 1 vs 3.9 ± 0.7 in group 2) or in BIS at LOC (48.7 ± 11.4 in group 1 vs 58.6 ± 21.7 in group 2). Conclusions: For similar propofol concentrations, patients with small brain tumors show higher BIS values on induction of anesthesia with propofol.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, D.A., C.S. Nunes, F. Lobo, M. Casal, L. M. Antunes, and P. Amorim (2008) "Brain tumors may alter the relationship between bispectral index values and propofol concentrations during induction of anesthesia," Journal of Clinical Anesthesia, 20(2): 116-121pt_PT
dc.identifier.doi10.1016/j.jclinane.2007.09.011pt_PT
dc.identifier.issn0952-8180
dc.identifier.urihttp://hdl.handle.net/10400.2/13887
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAnesthesia inductionpt_PT
dc.subjectBispectral index monitoringpt_PT
dc.subjectPropofol concentrationspt_PT
dc.titleBrain tumors may alter the relationship between bispectral index values and propofol concentrations during induction of anesthesiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage121pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage116pt_PT
oaire.citation.titleJournal of Clinical Anesthesiapt_PT
oaire.citation.volume20pt_PT
person.familyNameNunes
person.familyNameAmorim
person.givenNameCatarina S.
person.givenNamePedro
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0002-8357-0994
person.identifier.orcid0000-0001-7466-4174
person.identifier.scopus-author-id55429654100
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isAuthorOfPublication1ef321dd-4f09-493c-b801-e9a99b28947d
relation.isAuthorOfPublication.latestForDiscovery1ef321dd-4f09-493c-b801-e9a99b28947d

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