High Positive End-Expiratory Pressure (PEEP) with Recruitment Maneuvers versus Low PEEP during General Anesthesia for Surgery: A Bayesian Individual Patient Data Meta-analysis of Three Randomized Clinical Trials

Background: The influence of high positive end-expiratory pressure (PEEP) with recruitment maneuvers on the occurrence of postoperative pulmonary complications after surgery is still not definitively established. Bayesian anal ysis can help to gain further insights from the available data and provide a probabilistic framework that is easier to interpret. The objective was to estimate the posterior probability that the use of high PEEP with recruitment maneuvers is associated with reduced postoperative pulmonary complications in patients with intermediate-to-high risk under neutral, pessimistic, and opti mistic expectations regarding the treatment effect. Methods: Multilevel Bayesian logistic regression analysis was performed on individual patient data from three randomized clinical trials carried out on sur gical patients at intermediate to high risk for postoperative pulmonary com plications. The main outcome was the occurrence of postoperative pulmonary complications in the early postoperative period. This study examined the effect of high PEEP with recruitment maneuvers versus low PEEP ventilation. Priors were chosen to reflect neutral, pessimistic, and optimistic expectations of the treatment effect. Results: Using a neutral, pessimistic, or optimistic prior, the posterior mean odds ratio for high PEEP with recruitment maneuvers compared to low PEEP was 0.85 (95% credible interval, 0.71 to 1.02), 0.87 (0.72 to 1.04), and 0.86 (0.71 to 1.02), respectively. Regardless of prior beliefs, the posterior proba bility of experiencing a beneficial effect exceeded 90%. Subgroup analysis indicated a more pronounced effect in patients who underwent laparoscopy (odds ratio, 0.67 [0.50 to 0.87]) and those at high risk for postoperative pul monary complications (odds ratio, 0.80 [0.53 to 1.13]). Sensitivity analysis, considering severe postoperative pulmonary complications only or applying a different heterogeneity prior, yielded consistent results. Conclusions: High PEEP with recruitment maneuvers demonstrated a moderate reduction in the probability of postoperative pulmonary complica tion occurrence, with a high posterior probability of benefit observed consis tently across various prior beliefs, particularly among patients who underwent laparoscopy.

Description

[Catarina S. Nunes] - In: PROVHILO, iPROVE, and PROBESE investigators and the PROVE Network investigators .

URI

http://hdl.handle.net/10400.2/20118

Citation

Mazzinari, Guido Ph.D.1; Zampieri, Fernando G. M.D., Ph.D.2; Ball, Lorenzo M.D., Ph.D.3; Campos, Niklas S. M.D.4; Bluth, Thomas M.D.5; Hemmes, Sabrine N. T. M.D., Ph.D.6; Ferrando, Carlos M.D., Ph.D.7; Librero, Julian M.D.8; Soro, Marina M.D., Ph.D.9; Pelosi, Paolo M.D.10; Gama de Abreu, Marcelo M.D., Ph.D.11; Schultz, Marcus J. M.D., Ph.D.12; Serpa Neto, Ary M.D., M.Sc., Ph.D.13; for REPEAT on behalf of the PROVHILO, iPROVE, and PROBESE investigators and the PROVE Network investigators. High Positive End-expiratory Pressure (PEEP) with Recruitment Maneuvers versus Low PEEP during General Anesthesia for Surgery: A Bayesian Individual Patient Data Meta-analysis of Three Randomized Clinical Trials. Anesthesiology 142(1):p 72-97, January 2025. | DOI: 10.1097/ALN.0000000000005170