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Oxygen Increases Lung Inflammatory Response in Spontaneous One-Lung Ventilation in Rabbits: A Prospective Randomized Experimental Study

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dc.contributor.authorMachado, Humberto S.
dc.contributor.authorSá, P.
dc.contributor.authorNunes, Catarina S.
dc.contributor.authorCouceiro, A.
dc.contributor.authorSilva, A. Moreira da
dc.contributor.authorÁguas, A.
dc.date.accessioned2023-05-30T13:22:46Z
dc.date.available2023-05-30T13:22:46Z
dc.date.issued2014
dc.description.abstractStudy objective: The purpose of this study was to investigate if oxygen supplementation would increase lung inflammatory response in a spontaneous one-lung ventilation animal model, when compared to room-air oxygen fraction. Design: In vivo prospective randomized animal study Setting: University research laboratory Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 2 groups (n=10 each group). Groups (OS – Oxygen Supplemented, and NOS – Non-Oxygen Supplemented) were submitted to spontaneous One-Lung Ventilation (OLV) during 60 minutes; OS group had a 2-liter/minute oxygen supplement, and NOS group was kept on roomair. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung ventilation was achieved by administration of air into interpleural space, and left lung collapse was visually confirmed through the center of diaphragm. Clinical monitoring and arterial blood gas analyses were performed in all rabbits. Measurements: Lung histology plates were observed under light microscopy for quantification of inflammatory response (light, moderate and severe). Main results: All subjects had at least light inflammatory response. However, rabbits submitted to oxygen supplementation had a statistically significant value for the occurrence of moderate inflammation (p<0.001). The inflammatory cells found were mainly eosinophils and neutrophils in an average proportion of 80/20. Oxygen partial pressure increased in both groups with a higher proportion in OS group (p<0.001). Conclusion: In this spontaneous OLV model, the use of oxygen supplementation was associated with a greater inflammatory response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, H., P. Sá, C. Nunes, A. Couceiro, A. Moreira da Silva and A. Águas (2014). "Oxygen Increases Lung Inflammatory Response in Spontaneous One-Lung Ventilation in Rabbits: A Prospective Randomized Experimental Study." Journal of Anesthesia & Clinical Research 5: 489pt_PT
dc.identifier.doi10.4172/2155-6148.1000489pt_PT
dc.identifier.issn2155-6148
dc.identifier.urihttp://hdl.handle.net/10400.2/13909
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOMICSpt_PT
dc.relation.publisherversionhttps://www.longdom.org/open-access/oxygen-increases-lung-inflammatory-response-in-spontaneous-onelung-ventilation-in-rabbits-2155-6148.1000489.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOxygen supplementpt_PT
dc.subjectLung inflammatory responsept_PT
dc.subjectSpontaneous one-lung ventilationpt_PT
dc.titleOxygen Increases Lung Inflammatory Response in Spontaneous One-Lung Ventilation in Rabbits: A Prospective Randomized Experimental Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Anesthesia & Clinical Researchpt_PT
oaire.citation.volume05pt_PT
person.familyNameNunes
person.givenNameCatarina S.
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0002-8357-0994
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b

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