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Clinical variables related to propofol effect-site concentrations at recovery of consciousness after neurosurgical procedures

2005Journal article Restricted access
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dc.contributor.authorNunes, Catarina S.
dc.contributor.authorFerreira, David A.
dc.contributor.authorAntunes, Luís
dc.contributor.authorAmorim, Pedro
dc.date.accessioned2023-05-30T12:35:45Z
dc.date.available2023-05-30T12:35:45Z
dc.date.issued2005
dc.description.abstractTarget controlled infusion (TCI) systems and computer data acquisition software are increasingly used in anesthesia. It was hypothesized that the use of such systems might allow retrieval of information useful to anticipate the effect-site concentrations of propofol at which patients would recover from anesthesia. The goal of the study was to identify variables related to propofol effect-site concentrations at recovery of consciousness (ROC). Sixteen patients with a Glasgow of 15, ASA 1 or 2, subjected to neurosurgical procedures, received TIVA with TCI propofol and remifentanil. Data were collected every 5 seconds from Datex AS3 and Aspect A200XP (BIS). Effect-site TCI was used for propofol (initial effect target 5.0 mg/ml) and for remifentanil (initial plasma target 2.5 ng/ml). All clinical events were noted. Variables possibly related to propofol effect-site concentration at ROC were selected. Data are expressed as mean 6 SD. Effect-site propofol concentration at ROC was 1.3 6 0.5 mg/ml. A positive correlation was found between propofol effectsite concentration at ROC and: age (49.3 6 17 years) (P = 0.003); mean remifentanil dose during surgery (0.11 6 0.05 mg/kg/min) (P = 0.003); mean propofol dose during surgery (0.12 6 0.03 mg/kg/min) (P = 0.046); and remifentanil effect-site concentration at ROC (2.85 6 2.06 ng/ml) (P = 0.002). Propofol effect-site concentrations were not correlated with: weight, height, LBM, duration of anesthesia, minimum BIS at induction (30.4 6 6.8), time till minimum BIS (4.7 6 2.2 min), mean and median BIS during surgery (38.2 6 4.5 and 37.8 6 5.3). BIS-related variables were not useful as ROC predictors. Only drug variables and age correlated with propofol effectsite concentrations at ROC.pt_PT
dc.description.sponsorshipThe authors wish to acknowledge the Portuguese Foundation for Science and Technology (Lisbon, Portugal) for their financial support under project POSI/EEA-SRI/57607/2004.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes, Catarina S PhD; Ferreira, David A MVD; Antunes, Luís PhD; Amorim, Pedro MD. Clinical Variables Related to Propofol Effect-Site Concentrations at Recovery of Consciousness After Neurosurgical Procedures. Journal of Neurosurgical Anesthesiology 17(2):p 110-114, April 2005.pt_PT
dc.identifier.doi10.1097/01.ana.0000163198.02742.9dpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.2/13907
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwerpt_PT
dc.subjectAnalgesic i.v. remifentanilpt_PT
dc.subjectAnesthetics i.v. propofolpt_PT
dc.subjectReturn of consciousnesspt_PT
dc.subjectStatistical analysispt_PT
dc.titleClinical variables related to propofol effect-site concentrations at recovery of consciousness after neurosurgical procedurespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage114pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage110pt_PT
oaire.citation.titleJournal of Neurosurgical Anesthesiologypt_PT
oaire.citation.volume17pt_PT
person.familyNameDa Costa Nunes Duarte
person.familyNameAmorim
person.givenNameCatarina Sofia
person.givenNamePedro
person.identifier.ciencia-id691F-CDC2-E26A
person.identifier.orcid0000-0002-8357-0994
person.identifier.orcid0000-0001-7466-4174
person.identifier.scopus-author-id55429654100
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcc3069ec-f930-455f-9226-b77e5d2dc14b
relation.isAuthorOfPublication1ef321dd-4f09-493c-b801-e9a99b28947d
relation.isAuthorOfPublication.latestForDiscoverycc3069ec-f930-455f-9226-b77e5d2dc14b

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