Publication
Spontaneous one-lung ventilation increases the lung inflammatory response : an experimental pilot study
| dc.contributor.author | Machado, Humberto S. | |
| dc.contributor.author | Sá, Paula | |
| dc.contributor.author | Nunes, Catarina S. | |
| dc.contributor.author | Couceiro, António | |
| dc.contributor.author | Silva, Álvaro Moreira da | |
| dc.contributor.author | Águas, Artur | |
| dc.date.accessioned | 2015-03-03T11:35:47Z | |
| dc.date.available | 2015-03-03T11:35:47Z | |
| dc.date.issued | 2014-08-11 | |
| dc.description.abstract | Study objective: The purpose of this study was to investigate if spontaneous one-lung ventilation would induce any type of inflammatory lung response when compared to spontaneous two-lung ventilation and its intensity, by quantification of inflammatory cells in lung histology at the end of the procedure. Design: In vivo prospective randomised animal study Setting: University research laboratory Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 4 groups (n=5 each group). Groups 1 and 2 were submitted to one-lung ventilation, during 20 and 75 minutes respectively; groups 3 and 4 were submitted to two-lung ventilation during 20 and 75 minutes and considered controls. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung ventilation was achieved by administration of air into the interpleural space, and left lung collapse was visually confirmed through the centre of the diaphragm. Measurements: Lung histology preparations were observed under light microscopy for quantification of the inflammatory response (light, moderate and severe). Main results: All subjects had at least light inflammatory response. However, rabbits submitted to one-lung ventilation had a statistically significant value for the occurrence of moderate inflammation (p<0.05). The inflammatory response found included mainly eosinophils, with an average proportion of 75/25 to other polymorphonuclear cells. No differences between groups were found regarding gas exchange, heart rate and respiratory rate. Conclusions: In this spontaneous one-lung ventilation model, lung collapse was positively associated with a greater inflammatory response when compared to normal two-lung ventilation. | por |
| dc.identifier.citation | Machado, Humberto S. [et al.] - Spontaneous one-lung ventilation increases the lung inflammatory response : an experimental pilot study. "Journal of Anesthesia & Clinical Research" [Em linha]. ISSN 2155-6148. Vol. 8, nº 5 (2014), p. 1-5 | por |
| dc.identifier.doi | 10.4172/2155-6148.1000428 | |
| dc.identifier.issn | 2155-6148 | |
| dc.identifier.uri | http://hdl.handle.net/10400.2/3741 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | OMICS International | por |
| dc.relation.publisherversion | http://omicsonline.org/open-access/spontaneous-onelung-ventilation-increases-the-lung-inflammatory-response-an-experimental-pilot-study-2155-6148.1000428.php?aid=30807 | por |
| dc.subject | Inflammatory response | por |
| dc.subject | One-lung ventilation | por |
| dc.subject | Atelectasis | por |
| dc.title | Spontaneous one-lung ventilation increases the lung inflammatory response : an experimental pilot study | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | USA | por |
| oaire.citation.endPage | 5 | por |
| oaire.citation.startPage | 1 | por |
| oaire.citation.title | Journal of Anesthesia & Clinical Research | por |
| oaire.citation.volume | 8 | por |
| person.familyName | Nunes | |
| person.givenName | Catarina S. | |
| person.identifier.ciencia-id | 691F-CDC2-E26A | |
| person.identifier.orcid | 0000-0002-8357-0994 | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | cc3069ec-f930-455f-9226-b77e5d2dc14b | |
| relation.isAuthorOfPublication.latestForDiscovery | cc3069ec-f930-455f-9226-b77e5d2dc14b |