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Chemometric optimization of functional compound extraction from Artemisia annua L. and assessment of its antioxidant and antimicrobial properties

2026-03-02Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg06:Água Potável e Saneamento
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorFontoura, Bruno H.
dc.contributor.authorDallacorte, Lucas V.
dc.contributor.authorSimon, Anna P.
dc.contributor.authorMarchese, Amanda F.
dc.contributor.authorRodrigues, Michelle F. F.
dc.contributor.authorLima, Vanderlei A. de
dc.contributor.authorFernandes, Tiago
dc.contributor.authorCarpes, Solange T.
dc.contributor.authorMarchese, José A.
dc.date.accessioned2026-06-01T11:20:50Z
dc.date.available2026-06-01T11:20:50Z
dc.date.issued2026-03-02
dc.description.abstractArtemisia annua L. is a medicinal plant valued for its bioactive compounds, especially artemisinin. This study focused on improving the extraction of these compounds using a CCRD design, combining ethanol/water (0−100%) and extraction times (60−300 s), with a mechanical homogenizer (ultradisperser). The obtained extracts were analyzed by using spectrophotometric methods (UV−vis and HPLC-DAD) to determine the presence of phenolic compounds, flavonoids, and sesquiterpenes. Antioxidant and antimicrobial capacities were evaluated. Ethanol concentrations between 50 and 60% increased the extraction of phenolics with antioxidant potential, and concentrations greater than 70% were more effective for sesquiterpenes. Extracts with a higher artemisinin content showed strong antimicrobial activity, especially against Gram-positive bacteria. Multivariate analyses validated the relationships between the extracted compounds and their biological effects. The overall extraction condition was 50% (ethanol/ water, v/v) for 180 s, highlighting the biological potential of A. annua L. and the importance of optimizing extraction processes.eng
dc.description.sponsorshipWe further acknowledge the Araucária Foundation for the Support of Scientific and Technological Development of Paraná (FUNDAÇÃO ARAUCÁRIA)/SETI/NAPI Sudoeste (projects #282/2022 PDI and JDT2022271000024), as well as the Brazilian National Council for Scientific and Technological Development (CNPq) and the Coordination for the Improvement of Higher Education Personnel (CAPES) for granting research scholarships (BHF-CNPq/DAI #140275/2024-0, and LVD-CAPES #001). This study was further supported by the Portuguese Foundation for Science and Technology (FCT) through projects UIDP/00100/2020 [(10.54499/UIDP/00100/2020)], UIDB/00100/2020 [(10.54499/UIDB/00100/2020)], and LA/P/0056/2020 [(10.54499/LA/P/0056/2020)], as well as under contract CEECIND/02725/2018, within the scope of DL No. 57/2016, PolyBioPrint - 2023.14308.PEX.
dc.identifier.citationBruno H. Fontoura, Lucas V. Dallacorte, Anna P. Simon, Amanda F. Marchese, Michelle F.F. Rodrigues, Vanderlei A. de Lima, Tiago A. Fernandes, Solange T. Carpes, José A. Marchese, Chemometric Optimization of Functional Compound Extraction from Artemisia annua L. and Assessment of Its Antioxidant and Antimicrobial Properties, ACS Agric. Sci. Technol., 2026, 6, 716-731. https://doi.org/10.1021/acsagscitech.5c00629
dc.identifier.doi10.1021/acsagscitech.5c00629
dc.identifier.issn2692-1952
dc.identifier.urihttp://hdl.handle.net/10400.2/22094
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society
dc.relationCentro de Química Estrutural
dc.relationInstitute of Molecular Sciences
dc.relation.hasversionhttps://pubs.acs.org/doi/10.1021/acsagscitech.5c00629
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMedicinal plants
dc.subjectArtemisinin
dc.subjectResponse surface methodology
dc.subjectCentral Composite Design (CCD)
dc.subjectStatistical modeling
dc.titleChemometric optimization of functional compound extraction from Artemisia annua L. and assessment of its antioxidant and antimicrobial propertieseng
dc.typejournal article
dcterms.referenceshttps://pubs.acs.org/doi/suppl/10.1021/acsagscitech.5c00629/suppl_file/as5c00629_si_001.pdf
dspace.entity.typePublication
oaire.awardNumberUIDP/00100/2020
oaire.awardNumberLA/P/0056/2020
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleInstitute of Molecular Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0056%2F2020/PT
oaire.citation.endPage731
oaire.citation.issue5
oaire.citation.startPage716
oaire.citation.titleACS Agricultural Science & Technology
oaire.citation.volume6
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFernandes
person.givenNameTiago
person.identifier.ciencia-id8810-5C8A-08D0
person.identifier.orcid0000-0002-3374-612X
person.identifier.ridB-6777-2013
person.identifier.scopus-author-id24449123500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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