A carregar...
Projeto de investigação
Multifunctional BioMOFs for increased antimicrobial efficiency and antibiofilm applications
Financiador
Autores
Publicações
Coumarins in spirit beverages: sources, quantification, and their involvement in quality, quthenticity and food safety
Publication . Alves, Sheila Cristina Oliveira; Lourenço, Sílvia; Fernandes, Tiago; Canas, Sara
This comprehensive review is devoted to an under-exploited family of phenolic compounds, the coumarins, and the most relevant strands in which they are involved in some spirit beverages—wine spirit, brandy, whiskey, sugar-cane spirits (rum and cachaça) and grape marc spirit—with great importance worldwide in terms of production, trade and consumption. It gathers the key discoveries on the topic, considering the production process of each spirit beverage, and the related sources of coumarins (different kinds of wood used in the ageing stage), along with the factors that govern them and can influence the sensory properties of the aged beverages. An overview of the analytical methods available for their identification/quantification is also included, as well as the corresponding trends for the advancement of knowledge in this field. Moreover, the remarkable role of coumarins as nutraceuticals, their importance as chemical markers for authenticity purposes, and their relationship with the food safety of these spirit beverages are also addressed, highlighting the current gaps and issues, and providing clues for future research.
Innovating for tomorrow: industry 4.0’s role in sustainable healthcare
Publication . Ferreira, Ana Rita O.; Fernandes, Tiago
Purpose: It is essential for professionals to stay informed about the revolution we are witnessing and understand the related technical concepts in today’s rapidly evolving society. In addition to exploring how Industry 4.0 technologies—such as artificial intelligence (AI), the Internet of Things (IoT), big data, and blockchain—are transforming the healthcare sector, this literature review aims to address a crucial question: How can new technologies improve operational and environmental sustainability in healthcare while maintaining accessibility, safety, and equity?
Methods: A comprehensive literature study was conducted to analyze current research and discussions around the integration of Industry 4.0 technology in healthcare. This paper covers the various aspects of automation, data processing, system interconnection, ethical, financial, and infrastructure issues. Among the main topics discussed is data integration, which helps to enhance resource management, predictive analytics, and decision-making.
Results: Through international case studies (Mayo Clinic, Cleveland Clinic, Manifal Hospital, University College London Hospitals, Charité Hospital, Mount Sinai Hospital, Centro Hospitalar e Universitário de Coimbra) this review shows how these technologies improve patient outcomes, healthcare efficiency, and the environment. Significant problems should be warned about, including ethical issues about patient data security and privacy, unequal access to technological developments, the necessity of guaranteeing health information system interoperability, and economic viability concerns, particularly in countries or regions with limited resources.
Conclusions: Healthcare 4.0 has enormous potential for global justice and sustainability, but its ethical integrity, data security, and broad accessibility must be monitored. Although the healthcare sector will benefit much from the 4th industrial revolution, this analysis cautions about the related social and economic issues and inequalities. Encouraging ethical innovation will rely much on public policies to support this technological transition being implemented in a sustainable manner in the healthcare sector.
Optimization of extraction of bioactive compounds from piper corcovadensis C.DC leaves using a generalized linear model
Publication . Fontoura, Bruno Henrique; Ramos, Luciano de Souza; Dallacorte, Lucas Vinícius; Rodrigues, Michelle Fernanda Faita; Marchese, José Abramo; Fernandes, Tiago; Cunha, Mário Antônio Alves da; Lima, Vanderlei Aparecido de; Carpes, Solange Teresinha
This concerns P. corcovadensis, an endemic plant of Brazil commonly used by the population due to its therapeutic properties. Optimizing chemical extraction conditions is critical for increasing the availability of bioactive compounds from plants. These compounds have antioxidant potential derived from a plant’s specialized metabolism and can exhibit a variety of biological actions. Therefore, statistical tools such as the Random Forest and Lazy KStar machine learning algorithms were used to determine the optimal condition for the extraction of phenolic compounds from P. corcovadensis leaves, with model evaluated by coefficient of determination (R2), mean square root of calibration error (RMSEC), and residual predictive deviation (RPD). The optimal extraction condition was obtained using a mixture of 80/20% (ethanol/water) at 70 °C for 120 min. For those extracts, there were 11.64 ± 0.04 mg GAE g-1 and antioxidant activity of 21.27 ± 0.53 mmol Trolox g-1, 33.15 ± 11.66 mmol Trolox g-1, and 13.47 ± 1.37 mmol Fe2+ by DPPH, ABTS and FRAP tests. With this study, we have shown that mathematical modelling can also be helpful in experimental sciences and can be used to develop predictive models. It was possible to develop predictive models for total phenolic compounds determination using the Random Forest and Lazy KStar machine learning algorithms. The Random Forest algorithm performed very well for DPPH modelling, giving us the confidence to use it to prediction antioxidant activity.
Biopolymers in seed coating for sustainable agriculture
Publication . Sprey, Layanne Muniz; Fernandes, Tiago; Kirillov, Alexander M.; Sousa, Ana Catarina
The multibillion-dollar worldwide market for coated seeds is currently seeking new sustainable solutions that promote the use of natural (biobased) polymers for developing seed coating materials produced using clean methodologies. Seed coating is an effective method widely applied in modern agriculture. By uniformly depositing a variety of active ingredients on the seed surface, it is possible to obtain coated seeds with enhanced resistance, germination, and facilitated sowing. Moreover, seed coating is an attractive option for improving crop yield, resistance to biotic and abiotic factors, and restoring degraded soil systems. Petroleum derived polymers are commercially used in seed coating, which can negatively affect plants, soil, and pollinating animals. Biopolymer seed coatings offer various advantages for reducing environmental contamination, enhancing seed protection, and enabling the addition of beneficial microbial species that promote plant growth. Such seed coatings also improve seed germination, nutrient delivery, and sowing efficiency, while reducing reliance on chemical inputs and contributing to environmentally responsible agriculture. This review highlights the growing importance of biopolymers in seed coating and summarizes their multifaceted use in sustainable agricultural systems.
Unidades organizacionais
Descrição
Palavras-chave
METAL-ORGANIC FRAMEWORKS, COORDINATION CHEMISTRY, COORDINATION POLYMERS, ANTIMICROBIAL, ANTIBIOFILM,
Contribuidores
Financiadores
Entidade financiadora
Fundação para a Ciência e a Tecnologia, I.P.
Programa de financiamento
CEEC IND 2018
Número da atribuição
CEECIND/02725/2018/CP1572/CT0006