Ribeiro, Patrícia O.Antunes, Luis M.Nunes, Catarina S.Silva, Henrique B.Cunha, Rodrigo A.Tomé, Ângelo R.2021-05-132021-05-132015Ribeiro, Patrícia O. DVM, PhD*; Antunes, Luis M. DVM, PhD†‡; Nunes, Catarina S. MSc, PhD§‖; Silva, Henrique B. PhD*; Cunha, Rodrigo A. PhD*¶; Tomé, Ângelo R. PhD*# The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice, Anesthesia & Analgesia: May 2015 - Volume 120 - Issue 5 - p 1130-1137 doi: 10.1213/ANE.0000000000000636http://hdl.handle.net/10400.2/10731α2-Adrenoceptor agonists are used frequently in human and veterinary anesthesia as sedative/analgesic drugs. However, they can impair cognition. Little is known about the concentration-dependent effects of α2-adrenoceptor agonists on synaptic plasticity, the neurophysiological basis of learning and memory. Therefore, we investigated the effects of different concentrations of medetomidine, an α2-adrenoceptor agonist, on basal excitatory synaptic transmission and on 2 forms of synaptic plasticity: paired-pulse facilitation (PPF) and long-term potentiation (LTP).engAdrenergic alpha-2 receptor agonistsAge factorsAnimalsCA1 Region, HippocampalDose-response relationship, DrugEvoked potentialsExcitatory postsynaptic potentialsFemaleIn vitro techniquesLong-term synaptic depressionMedetomidineMemoryMiceMice, Inbred BALB CNeuronal plasticityPyramidal cellsSynaptic transmissionTime factorsjournal article10.1213/ANE.0000000000000636