Nunes, Catarina S.Ferreira, David A.Antunes, LuísLobo, FranciscoSantos, Isabel A.Amorim, Pedro2023-05-292023-05-292009Nunes, C.S., D. Ferreira, L. Antunes, F. Lobo, I. Santos, and P. Amorim (2009) "Individual Effect-Site Concentrations of Propofol at Return of Consciousness are Related to the Concentrations at Loss of Consciousness and Age in Neurosurgical Patients," Journal of Clinical Anesthesia, 21(1): 3-81873-4529http://hdl.handle.net/10400.2/13884Study Objective: To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design: Prospective study. Setting: Operating room. Patients: 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score N 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions: A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL 1 . Main Results: Propofol concentration at LOC was 4.9 ± 1 μg mL 1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μg mL 1 and 3.41 ± 1.5 ng mL 1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions: The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.engConsciousness, loss ofConsciousness, return toDrug dosages: effect-site concentrationsPropofol, hypnotic dosejournal article10.1016/j.jclinane.2008.06.011