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|Título:||Spontaneous one-lung ventilation increases the lung inflammatory response : an experimental pilot study|
|Autor:||Machado, Humberto S.|
Nunes, Catarina S.
Silva, Álvaro Moreira da
|Citação:||Machado, Humberto S. [et al.] - Spontaneous one-lung ventilation increases the lung inflammatory response : an experimental pilot study. "Journal of Anesthesia & Clinical Research" [Em linha]. ISSN 2155-6148. Vol. 8, nº 5 (2014), p. 1-5|
|Resumo:||Study objective: The purpose of this study was to investigate if spontaneous one-lung ventilation would induce any type of inflammatory lung response when compared to spontaneous two-lung ventilation and its intensity, by quantification of inflammatory cells in lung histology at the end of the procedure. Design: In vivo prospective randomised animal study Setting: University research laboratory Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 4 groups (n=5 each group). Groups 1 and 2 were submitted to one-lung ventilation, during 20 and 75 minutes respectively; groups 3 and 4 were submitted to two-lung ventilation during 20 and 75 minutes and considered controls. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung ventilation was achieved by administration of air into the interpleural space, and left lung collapse was visually confirmed through the centre of the diaphragm. Measurements: Lung histology preparations were observed under light microscopy for quantification of the inflammatory response (light, moderate and severe). Main results: All subjects had at least light inflammatory response. However, rabbits submitted to one-lung ventilation had a statistically significant value for the occurrence of moderate inflammation (p<0.05). The inflammatory response found included mainly eosinophils, with an average proportion of 75/25 to other polymorphonuclear cells. No differences between groups were found regarding gas exchange, heart rate and respiratory rate. Conclusions: In this spontaneous one-lung ventilation model, lung collapse was positively associated with a greater inflammatory response when compared to normal two-lung ventilation.|
|Versão do Editor:||http://omicsonline.org/open-access/spontaneous-onelung-ventilation-increases-the-lung-inflammatory-response-an-experimental-pilot-study-2155-6148.1000428.php?aid=30807|
|Aparece nas colecções:||Ciências da Vida - Artigos em revistas internacionais / Papers in international journals|
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|paper-2155-6148.1000428.pdf||1,8 MB||Adobe PDF||Ver/Abrir|
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