Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.2/1955
Título: Noninvasive evaluation of retinal leakage using optical coherence tomography
Autor: Bernardes, Rui
Santos, Torcato
Serranho, Pedro
Lobo, Conceição
Cunha-Vaz, José
Palavras-chave: Optical coherence tomography
Retinal leakage analyzer
Fluorescein angiography
Blood-retinal barrier
Data: 2011
Citação: Bernardes, Rui et al. - Noninvasive evaluation of retinal leakage using optical coherence tomography. "Ophthalmologica" [Em linha]. ISSN 0030-3755. Vol. 226, nº 2 (Jul. 2011), p. 29-36
Relatório da Série N.º: 226
Resumo: Purpose: To demonstrate the association between changes in the blood-retinal barrier (BRB) identified by fluorescein leakage and those in the optical properties of the human retina determined by optical coherence tomography (OCT) and show how these changes can be quantified and their location identified within the retina. Methods: Two imaging techniques were applied: the retinal leakage analyzer, to map BRB function into intact or disrupted regions, and OCT, to measure refractive index changes along the light path within the human ocular fundus. Results: A total of 140 comparisons were made, 77 between areas of regions receiving the same classification (intact or disrupted BRB) and 63 between areas of regions receiving distinct classifications, from 4 pathological cases: 2 eyes with nonproliferative diabetic retinopathy and 2 eyes with wet age-related macular degeneration. In all cases, the distribution of OCT data between regions of intact and regions of disrupted BRB, identified by the retinal leakage analyzer, was quantified and was statistically significantly different (p < 0.001). In addition, it was found that the differences could be localized in the retina to specific structural sequences. Conclusions: Using a novel method to analyze OCT data, we showed that it may be possible to quantify differences in the extracellular compartment in eyes with retinal disease and alterations of the BRB. Based on quantitative techniques, our findings demonstrate the presence of indirect information on the BRB status within noninvasive OCT data.
Peer review: yes
URI: http://hdl.handle.net/10400.2/1955
ISSN: 0030-3755
Versão do Editor: http://content.karger.com/ProdukteDB/produkte.asp?
doi=10.1159/000326268
Aparece nas colecções:Ciências e Tecnologia - Artigos em revistas internacionais / Papers in international journals

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